TY - JOUR AU - Rahim, A. AU - Ali, R. AU - Islam, A. PY - 2016/05/01 Y2 - 2024/03/28 TI - Studies of Antimicrobial Activity of 2',4',5'- and 2',3',4'-Trimethoxy Flavanones JF - Journal of Scientific Research JA - J. Sci. Res. VL - 8 IS - 2 SE - Section B: Chemical and Biological Sciences DO - 10.3329/jsr.v8i2.26622 UR - https://www.banglajol.info/index.php/JSR/article/view/26622 SP - 209-216 AB - <div><p> </p><p>2',4',5'- and 2',3',4'-trimethoxy flavanones have been synthesized starting with 2-hydroxyacetophone and substituted aldehyde. Antibacterial activities of the flavanones have been tested along with their corresponding chalcones against two human pathogenic bacteria (<em>Streptococcus-</em><em>b</em><em>-haemolyticus </em>and  <em>Klebsiella sp. (G<sup>-</sup>)</em>). Antifungal activities of the flavanones have also been investigated against  two plants pathogenic mold fungi (<em>Rhizactonia solani Sclerotium rolfsii</em>). The structures of the synthesized compounds have been characterized with the help of  UV, IR and <sup>1</sup>H NMR and <sup>13</sup>C-NMR spectra. The antibacterial and antifungal screening were performed <em>in vitro </em>by the filter paper disc diffusion method and poisoned food technique. The flavanones showed antibacterial activity while no activity was observed to their corresponding chalcones against the tested bacteria. On the other hand, chalcones and their corresponding flavanones both showed fungicidal activities.</p><p><span style="font-family: Times New Roman;"><br /></span></p></div> ER -