Synthesis of Biheterocycles Containing Indole Nucleus and Their Antibacterial Activity

Authors

  • S. Jain Vikram University
  • B. N. Reddy
  • K. S. Rao

DOI:

https://doi.org/10.3329/jsr.v4i1.7821

Keywords:

Indole-3-carboxaldehydes, Active methylene compounds, Base, Hydrazine hydrat, , Pyrazoles

Abstract

Indole-3-carboxaldehydes (1a-d) undergo condensation with ethyl cyanoacetate and malononitrile to give the acrylonitrile 2a-d and 3a-d which on reaction with hydrazine hydrate yield 3,5-diamino-5-hydroxy-4-(3-indolylmethylene)pyrazoles (4a-d) and 3-amino-5-hydroxy -4-(3-indolylmethylene)pyrazoles (5a-d), respectively. The new compounds were also screened for their antibacterial activity.

Keywords:  Indole-3-carboxaldehydes ; Active methylene compounds; Base; Hydrazine hydrate;  Pyrazoles.

© 2012 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

doi: http://dx.doi.org/10.3329/jsr.v4i1.7821

 

J. Sci. Res. 4 (1), 273-278 (2012)

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Author Biographies

S. Jain, Vikram University

Laboratory of Heterocycles, School of studies in chemistry & Biochemistry, Vikram University, Ujjain, Madhya Pradesh-456010, India

B. N. Reddy

  B. Nagi Reddy

Laboratory of Heterocycles, School of studies in Chemistry & Biochemistry

Vikram University

Ujjain, Madhya Pradesh-456010, India

       

      

K. S. Rao

 K. Sambasiva Rao

CavinKare Research Centre,

Ponnumalli, Chennai, Tamilnadu- 600032, India

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Published

2011-12-26

How to Cite

Jain, S., Reddy, B. N., & Rao, K. S. (2011). Synthesis of Biheterocycles Containing Indole Nucleus and Their Antibacterial Activity. Journal of Scientific Research, 4(1), 273. https://doi.org/10.3329/jsr.v4i1.7821

Issue

Vol. 4 No. 1 (2012)

Section

Section B: Chemical and Biological Sciences

License

© Journal of Scientific Research

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