Biological Activity Study on a <i>Malvaceae</i> Plant: <i>Bombax ceiba</i>

Authors

  • M. K. Islam Department of Pharmacy, Jagannath University
  • J. A. Chowdhury Department of Pharmaceutical Technology, University of Dhaka.
  • I. Z. Eti Quality Control Department, ACI Limited

DOI:

https://doi.org/10.3329/jsr.v3i2.5162

Keywords:

Bombax ceiba, Brine shrimp lethality bioassay, Disc diffusion method.

Abstract

The work described in this paper details the biological investigation on Bombax ceiba, species of Malvaceae. The methanol crude extract of Bombax ceiba was fractionated with kupchan method and n-hexane, carbon tetrachloride, chloroform fraction were made for  screening the antimicrobial and antitumor potentials using disc diffusion method and brine shrimp lethality bioassay respectively. An established antibiotic (kanamycin, 30µg/disc) and cytotoxic agent (vincristine sulphate) were used to compare the results. From the graphs the concentration of methanolic crude extract give LC50 (50% mortality) value of 3.90mg/ml. LC90 was also determined from the graph to establish the therapeutic index and the value was found 150.0mg/ml. The four fractions were assayed for antimicrobial screening and the carbon tetrachloride fraction showed most prominent zone of inhibition against a number of bacterial and fungal strains.

Keywords: Bombax ceiba; Brine shrimp lethality bioassay; Disc diffusion method.

© 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

doi:10.3329/jsr.v3i2.5162                J. Sci. Res. 3 (2), 445-450 (2011)

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Author Biographies

M. K. Islam, Department of Pharmacy, Jagannath University

Lecturer

Department of Pharmacy, Jagannath University. 9-10 Chittaranjan Avenue,  Dhaka-1100, Bangladesh.

J. A. Chowdhury, Department of Pharmaceutical Technology, University of Dhaka.

Assistant Professor,

Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka.

I. Z. Eti, Quality Control Department, ACI Limited

Senior QC Officer, Quality Control Department, ACI Limited, Narayanganj, Dhaka. Bangladesh.

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Published

2011-04-29

How to Cite

Islam, M. K., Chowdhury, J. A., & Eti, I. Z. (2011). Biological Activity Study on a <i>Malvaceae</i> Plant: <i>Bombax ceiba</i>. Journal of Scientific Research, 3(2), 445–450. https://doi.org/10.3329/jsr.v3i2.5162

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Section

Section B: Chemical and Biological Sciences