Synthesis, Characterization and In-Silico Analysis of New 2-Pyrazolines

Authors

  • T. Saroja Department of Chemistry, Guru Nanak College (Autonomous), Velachery, Chennai – 600042, India
  • R. M. Ezhilarasi Department of Chemistry, Guru Nanak College (Autonomous), Velachery, Chennai – 600042, India
  • V. Selvamani Department of Chemistry, Sri Sarada Niketan College of Arts & Science for Women, Salem – 636354, India
  • S. Mahalakshmi Department of Chemistry, Pachaiyappa’s College, Chennai, India

DOI:

https://doi.org/10.3329/jsr.v13i1.46995

Abstract

Heterocyclic compounds such as pyrazolines, pyrimidines, oxazole and isoxazole exhibit different pharmacological activities. The current study involves synthesis of new 2-pyrazolines. The synthesis involves the cyclocondensation reaction of substituted chalcones with (4-fluorophenylthio)acetic acid hydrazide (FTAH) under reflux. The chalcones (C1-C7 / 1a-1g) were synthesized from the reaction of substituted acetophenone with substituted benzaldehyde and FTAH was prepared from 4-fluro thiophenol. New 2-pyrazolines were obtained in good yields (60-70 %). All the compounds were characterized by FT-IR, 1H, 13C NMR and mass spectra. PASS analysis was carried out for the 2-pyrazolines synthesized (P1-P7 / 3a-3g).

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Published

2021-01-01

How to Cite

Saroja, T., Ezhilarasi, R. M., Selvamani, V., & Mahalakshmi, S. (2021). Synthesis, Characterization and In-Silico Analysis of New 2-Pyrazolines. Journal of Scientific Research, 13(1), 183–194. https://doi.org/10.3329/jsr.v13i1.46995

Issue

Section

Section B: Chemical and Biological Sciences