<i>In Vitro</i> Assessment of Antioxidant, Thrombolytic, Antimicrobial Activities of Medicinal Plant <i>Pandanus odoratissimus L.</i> Leaves Extract

  • F. I. Penu Department of Pharmacy, World University of Bangladesh (WUB), 151/8 Green Road, Dhaka-1205, Bangladesh
  • S. M. Ivy Department of Pharmacy, World University of Bangladesh (WUB), 151/8 Green Road, Dhaka-1205, Bangladesh
  • F. Ahmed Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
  • J. Uddin Department of Pharmacy, World University of Bangladesh (WUB), 151/8 Green Road, Dhaka-1205, Bangladesh
  • M. S. Hossain Department of Pharmacy, World University of Bangladesh (WUB), 151/8 Green Road, Dhaka-1205, Bangladesh
  • Z. K. Labu Department of Pharmacy, World University of Bangladesh (WUB), 151/8 Green Road, Dhaka-1205, Bangladesh

Abstract

The present study was carried out to investigate phytochemical, antioxidant; antimicrobial, thrombolytic activity and estimate total phenolic, total flavonoid content of Pandanus odoratissimus (p.odoratissimus) leaves of methanol extract. In thrombolytic activity, aqueous soluble fraction (AQSF) exhibited highest percentage (46.58 %) of potential to lyse blood clot compared to standard drug streptokinase (69.52 %). In antimicrobial assay, dichloromethane soluble fraction (DCMSF) explored the highest diameter of clear zone of inhibition against both gram positive (19.60 ± 0.12 mm) and gram negative (20.00 ± 0.20 mm) bacteria compared to standard antibiotic, Kanamycin (50.00 ± 0.19). Levels of antioxidant were determined by DPPH assay followed by calculated IC50 values of different Kupchan extracts. The methyl soluble fraction (MSF) showed the lowest level of IC50 value (36.70 ± 0.32 µg/mL) in comparison to ascorbic acid (12.48 ± 0.09 µg/mL) while MSF disclosed the maximum level (62.19 ±  0.26 mg of GAE/g of extract) of total phenolic content in the extracts of P. odoratissimus. This study was conducted to validate the P. odoratissimus leaves used as a folk medicine such as, antioxidant, thrombolytic, and antimicrobial potential.

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Abstract
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Published
2020-05-01
How to Cite
Penu, F., Ivy, S., Ahmed, F., Uddin, J., Hossain, M., & Labu, Z. (2020). <i>In Vitro</i> Assessment of Antioxidant, Thrombolytic, Antimicrobial Activities of Medicinal Plant <i>Pandanus odoratissimus L.</i&gt; Leaves Extract. Journal of Scientific Research, 12(3), 379-390. https://doi.org/10.3329/jsr.v12i3.44225
Section
Section B: Chemical and Biological Sciences