Antibacterial and Antifungal Evaluation of Chloroflavones

Authors

  • M. A. Rahim Department of Chemistry, University of Chittagong, Chittagong 4331, Bangladesh
  • M. M. H. Bhuiyan Department of Chemistry, University of Chittagong, Chittagong 4331, Bangladesh
  • M. M. Matin Department of Chemistry, University of Chittagong, Chittagong 4331, Bangladesh
  • M. R. Alam Department of Chemistry, University of Chittagong, Chittagong 4331, Bangladesh

DOI:

https://doi.org/10.3329/jsr.v10i1.33858

Keywords:

Antibacterial activity, Antifungal activity, MBC, MIC, Flavones.

Abstract

Two chloroflavones, 6 and 7 along with their corresponding chalcones, 4 and 5 have been tested for antibacterial and antifungal activities against six human pathogenic bacteria viz. Bacillus cereus (G+), Staphylococcus aureus (G+), Escherichia coli (G-), Vibrio choloriae (G-), Pseudomonas aeruginosa (G-), and Salmonella typhi (G-), and four plant as well as mold fungi viz. Aspergillus flavus, Aspergillus ochraceus, Aspergillus niger and Rhizopus spp.. The antibacterial and antifungal screens of the synthesized compounds were performed in vitro by the filter paper disc diffusion method and the poisoned food technique, respectively. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of these synthesized compounds in comparison to ampicillin were also determined by broth micro-dilution method. Some of them were found to possess significant activity, when compared to standard drugs.

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Author Biographies

M. A. Rahim, Department of Chemistry, University of Chittagong, Chittagong 4331, Bangladesh

Ph.D Researcher

Dept of Chemistry

University of Chittagong, Chittagong

M. M. H. Bhuiyan, Department of Chemistry, University of Chittagong, Chittagong 4331, Bangladesh

Professor
Dept of Chemistry
University of Chittagong, Chittagong

M. M. Matin, Department of Chemistry, University of Chittagong, Chittagong 4331, Bangladesh

Professor
Dept of Chemistry
University of Chittagong, Chittagong

M. R. Alam, Department of Chemistry, University of Chittagong, Chittagong 4331, Bangladesh

M.Sc Researcher
Dept of Chemistry
University of Chittagong, Chittagong

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Published

2018-01-01

How to Cite

Rahim, M. A., Bhuiyan, M. M. H., Matin, M. M., & Alam, M. R. (2018). Antibacterial and Antifungal Evaluation of Chloroflavones. Journal of Scientific Research, 10(1), 67–76. https://doi.org/10.3329/jsr.v10i1.33858

Issue

Vol. 10 No. 1 (2018)

Section

Section B: Chemical and Biological Sciences

License

© Journal of Scientific Research

Creative Commons License

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