New Spectrophotometric Methods for Estimation of Perindopril Erbumine in Bulk and Pharmaceutical Formulations

  • A. Unnisa KVSR Siddhartha College of Pharmaceutical Sciences
  • K. V. G. Raju KVSR Siddhartha College of Pharmaceutical Sciences
  • K. Balaji KVSR Siddhartha College of Pharmaceutical Sciences
  • A. N. Jyothi KVSR Siddhartha College of Pharmaceutical Sciences
  • T. S. Kumar KVSR Siddhartha College of Pharmaceutical Sciences
Keywords: Perindopril erbumine, Spectrophotometry, Cobalt-thiocyanate, Citricacid-acetic anhydride.

Abstract

Three rapid, simple, inexpensive, precise, and accurate spectrophotometric procedures were developed for the determination of Perindopril erbumine (PPE) using cobalt-thiocyanate, citric acid and 2,3- dichloro-5,6-dicyano benzoquinone in bulk sample and in dosage forms. The procedures are based on the coordination complex of the drug (electron donor) and the chromogenic reagents used. The colored products are extracted into non aqueous solvents and measured spectrophotometrically at the optimum ?maxfor each complex. Regression analysis of Beer-Lambert plots showed good correlation in the concentration range of 30-70 µg mL?1, 4-20 µg mL?1 and 20-60 µg mL?1 for cobalt-thiocyanate, citric acid and 2,3- dichloro-5,6-dicyano benzoquinone, respectively. The apparent molar absorptivity, Sandells sensitivity, detection and quantification limits were calculated. The developed methods were successfully applied for the determination of PPE in bulk and pharmaceutical formulations without any interference from common excipients and hence can be used for their routine analysis.

 

Keywords: Perindopril erbumine; Spectrophotometry; Cobalt-thiocyanate; Citricacid-acetic anhydride.

 

© 2014 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

 

doi: http://dx.doi.org/10.3329/jsr.v6i2.16106

J. Sci. Res. 6 (2), 319-327 (2014)

Downloads

Download data is not yet available.
Abstract
966
PDF
1334

Author Biography

A. Unnisa, KVSR Siddhartha College of Pharmaceutical Sciences
Asst. professor
Department of Pharmaceutical Analysis,

Published
2014-04-24
How to Cite
Unnisa, A., Raju, K. V. G., Balaji, K., Jyothi, A. N., & Kumar, T. S. (2014). New Spectrophotometric Methods for Estimation of Perindopril Erbumine in Bulk and Pharmaceutical Formulations. Journal of Scientific Research, 6(2), 319-327. https://doi.org/10.3329/jsr.v6i2.16106
Section
Section B: Chemical and Biological Sciences