Preventive Effect of Ganoderma lucidum on Paracetamol-induced Acute Hepatotoxicity in Rats
The effect of Ganoderma lucidum in paracetamol-induced acute hepatotoxicity was investigated on Wistar rats in the present study. Hepatotoxicity was induced by oral administration of paracetamol (500 mg/kg of body weight) for 7 consecutive days. The extent of liver damage was studied by assessing biochemical parameters comprising of plasma aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH), total bilirubin (TB) and total plasma total protein (TP). Oral administration of paracetamol significantly increased the plasma levels of AST, ALT, ALP and LDH with concomitant decrease of TP. The feeding of G. lucidum (1% powder with basal food) significantly reversed the plasma levels of ALT, AST, ALP, LDH, and TP nearly to those of the normal rats. Thus, the results of the present demonstrate that the G. lucidum has significant hepatoprotective activity against paracetamol induced acute hepatotoxicity in rats.
How to Cite
© Journal of Scientific Research
Articles published in the "Journal of Scientific Research" are Open Access articles under a Creative Commons Attribution-ShareAlike 4.0 International license (CC BY-SA 4.0). This license permits use, distribution and reproduction in any medium, provided the original work is properly cited and initial publication in this journal. In addition to that, users must provide a link to the license, indicate if changes are made and distribute using the same license as original if the original content has been remixed, transformed or built upon.