TY - JOUR AU - Roy, Suvash Chandra AU - Sajeeb, BK AU - Muhit, Md Abdul AU - Bachar, Sitesh C PY - 2019/09/22 Y2 - 2024/03/29 TI - Evaluation of Antioxidant and Cytotoxic Activities of Aerial Parts of Adiantum capillus-veneris L. Growing in Bangladesh JF - Dhaka University Journal of Pharmaceutical Sciences JA - Dhaka Univ. J. Pharm. Sci VL - 18 IS - 2 SE - Articles DO - 10.3329/dujps.v18i2.43264 UR - https://www.banglajol.info/index.php/JPharma/article/view/43264 SP - 217-222 AB - <p>The present study evaluated the antioxidant and cytotoxic activities of methanolic extract of aerial parts of <em>Adiantum capillus-veneris </em>L. and its different solvent fractions. The <em>in vitro </em>antioxidant activity was assessed by using 2,2’-diphenyl-1-picrylhydrazyl (DPPH) radicals. The analysis revealed that ethyl acetate soluble fraction had the highest DPPH radicals scavenging property with IC50 value of 1.05 μg/ml as compared to positive control ascorbic acid (IC50 = 1.34 μg/ml). In addition, <em>ex vivo </em>cytotoxicity assay of <em>A. capillus-veneris </em>L. extract and its different fractions were performed against HELA cells line where 5-Fluorouracil was used as positive control. The result demonstrated that ethyl acetate and n-hexane soluble fractions showed prominent cytotoxicity with IC50 value of 5.68 μg/ml and 17.15 μg/ml, respectively. The study affirmed that superior antioxidant and cytotoxic activities were shown by ethyl acetate soluble fraction of methanolic extract of aerial parts of <em>A. capillus-veneris </em>L. growing in Bangladesh which indicate the presence of bioactive phytoconstituents in the extractives.</p><p>Dhaka Univ. J. Pharm. Sci. 18(2): 217-222, 2019 (December)</p> ER -