TY - JOUR AU - Uddin, Jalal AU - Julie, Azima Sultana AU - Ali, Md Haider AU - Islam, Md Nurul AU - Khan, Shah Alam AU - Labu, Zubair Khalid PY - 2016/06/28 Y2 - 2024/03/29 TI - Antimicrobial, Thrombolytic, Membrane Stabilizing Activities and Total Flavonoid Content of Various Partitionates of Aerial Parts of Eclipta alba (L.) Hassk JF - Dhaka University Journal of Pharmaceutical Sciences JA - Dhaka Univ. J. Pharm. Sci VL - 14 IS - 2 SE - Articles DO - 10.3329/dujps.v14i2.28512 UR - https://www.banglajol.info/index.php/JPharma/article/view/28512 SP - 207-213 AB - <p><em>Eclipta alba </em>is a medicinal herb belonging to the family of Asteraceae. Locally it is known as Kalokeshi and has a history of ethno-medicinal properties. The crude ethanolic extract of <em>E. alba </em>leaves was partitioned successively by solvents of different polarities. The crude extract along with different partitionates was evaluated for their possible antimicrobial, thrombolytic and membrane stabilizing activities. In this study, <em>n</em>-hexane soluble fraction (HXSF) showed 55.56% maximum activity against thrombosis in comparison with streptokinase (SK) 62.67%. For hypotonic solution- and heat-induced conditions, the <em>n</em>-hexane soluble fractionate (67.35 ± 0.50%) significantly inhibited the haemolysis of HRBCs by 67.35 ± 0.50% and 62.12 ± 0.69%, respectively as compared to the standard acetyl salicylic acid (77.91 ± 0.29%). The ethanol extract of the plant showed higher inhibitory action against <em>Staphylococcus aureus, Bacillus subtilis</em>, <em>Proteus mirabilis </em>and <em>Pseudomonas fluroescens</em>. The total flavonoid content was quite significant in ethanolic extract (142.17 ± 0.15 mg/g). Hence, the results of the present study revealed that the leaves of this traditional medicinal plant are a remedy for thrombosis, red blood cell membrane stabilization and microbial infections against some human pathogens.</p><p>Dhaka Univ. J. Pharm. Sci. 14(2): 207-213, 2015 (December)</p> ER -