TY - JOUR AU - Razib, BM Mahbubul Alam AU - Ullah, Md. Ashik AU - Azad, Mohammad Abdul Kalam AU - Sultana, Rebeka AU - Yasmin, Hasina AU - Hasnat, Abul PY - 2007/06/20 Y2 - 2024/03/28 TI - Validation and Application of a Modified RP-HPLC Method for the Quantification of Desloratadine in Pharmaceutical Dosage Forms JF - Dhaka University Journal of Pharmaceutical Sciences JA - Dhaka Univ. J. Pharm. Sci VL - 5 IS - 1 SE - Articles DO - 10.3329/dujps.v5i1.219 UR - https://www.banglajol.info/index.php/JPharma/article/view/219 SP - 1-4 AB - The purpose of the study was to develop a simple, sensitive and rapid RP-HPLC method for the determination of desloratadine in marketed products. Chromatographic determination was performed in a reverse phase C18 column (250 mm × 3.3 mm I.D. , 5?m particle size) using a mixture of acetonitrile ? n-pentane sulphonic acid sodium salt monohydrate, adjusted to pH 3.0&plusmn; 0.05 with phosphoric acid (60? 40 v/v) as mobile phase and delivered at a flow rate of 1 ml/min. The UV detection was set at 254 nm. The calibration range was from 2.0 to 40 ?g/ml. The method was validated in term of linearity (r2>0.98, RSD= 1.958%), precision (RSD=3.757 %) and accuracy (deviation&gt;2.653%, RSD&gt; 2.203%). The limit of quantification was 2 ?g/ml and the limit of detection was 0.1 ?g/ml. The linear ranges of desloratadine were 20.23 &plusmn; 0.368 ?g/ml and 6.545 &plusmn; 0.0495 ?g/ml in tablet (potency = 99.175 &plusmn; 0.718 %) and syrup (potency = 101.15 &plusmn; 1.838 %) respectively. The potency of desloratadine in marketed products was determined by this method with acceptable precision and reproducibility.<b>Keywords:</b> Desloratadine, marketed products, RP-HPLC, development of a methodDhaka Univ. J. Pharm. Sci. Vol.5(1-2) 2006The full text is of this article is available at the <a href=" http://www.pharmadu.net/dujps/Journals/Article_01.pdf" target="_blank">Dhaka Univ. J. Pharm. Sci.</a> website ER -