TY - JOUR AU - Morshed, MH AU - Islam, MF AU - Yousuf, MA AU - Hossain, GMG AU - Khanam, JA AU - Salam, MA PY - 2012/03/02 Y2 - 2024/03/29 TI - Synthesis and Antimicrobial Screening of Three Triazole Derivatives JF - Dhaka University Journal of Pharmaceutical Sciences JA - Dhaka Univ. J. Pharm. Sci VL - 10 IS - 1 SE - Articles DO - 10.3329/dujps.v10i1.10014 UR - https://www.banglajol.info/index.php/JPharma/article/view/10014 SP - 43-47 AB - <p>Due to the medicinal importance of triazole derivatives, the antimicrobial property of three synthesized triazole derivatives were screened <em>in vitro </em>against some Gram positive and Gram negative pathogenic bacteria and some pathogenic fungi. In this study, three compounds 2-(5-mercapto-4-phenyl-4H-[1,2,4] triazole-3-yl]-cyclohexa- 1,5-dienol (S<sub>1</sub>), 2-[5-mercapto-4-(2-mercapto-phenyl)-4H- [1,2,4] triazole-3-yl]-phenol (S<sub>2</sub>) and 4-[3-(2-hydroxyphenyl)- 5-mercapto-[1,2,4] triazole-4-yl]-benzene sulfonamide (S<sub>3</sub>) have been synthesized. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were assessed by serial dilution technique. The compounds showed moderate antimicrobial activity against all the tested organisms and the results are comparable to standard antibiotic kanamycin. The MIC values of the compounds were found to be in the range of 16~64&mu;g/ml. The low MIC and MBC values and high sensitivity of pathogenic microorganisms to the compounds led to conclude that the triazole derivatives have potential antimicrobial properties.</p> <p>DOI: <a href="http://dx.doi.org/10.3329/dujps.v10i1.10014">http://dx.doi.org/10.3329/dujps.v10i1.10014</a></p> <p><em>DUJPS </em>2011; 10(1): 43-47</p> ER -