TY - JOUR AU - Islam, Md Saiful AU - Rahman Khan, Md Ziaur AU - Khatun, Masuda AU - Chowdhury, Jakir Ahmed AU - Reza, Md Selim PY - 2012/03/02 Y2 - 2024/03/28 TI - Studies on Bio-adhesion of Matrix Tablets: II.Comparison on Bio-adhesion Strength and Release Profiles of Theophylline Anhydrous and Its Sodium Glycinate Salt JF - Dhaka University Journal of Pharmaceutical Sciences JA - Dhaka Univ. J. Pharm. Sci VL - 10 IS - 1 SE - Articles DO - 10.3329/dujps.v10i1.10008 UR - https://www.banglajol.info/index.php/JPharma/article/view/10008 SP - 1-7 AB - <p>Controlled release matrix tablets of Theophylline anhydrous and Theophylline sodium glycinate were prepared with different types of bio-adhesive polymers e.g. HPMC 15 &amp; 50 cps, Gelatin, PVP K-30, Na-CMC and Xanthan gum. Tablets, prepared by direct compression method were subjected to <em>in-vitro </em>drug dissolution for 8 hours in 0.1 N hydrochloric acid (pH 1.2) using a thermal shaker at 50 rpm at 37 &plusmn; 0.5&ordm;C. The bio-adhesive property was investigated in terms of retention time following <em>in-vitro </em>wash-off method by Lehr <em>et al. </em>The anhydrous and corresponding salt form was used to investigate whether physical variation of Theophylline molecule can cause any change in release and bio-adhesion property or not. In most of the cases it is found that salt form releases greater percentage of active drug than its corresponding anhydrous form. Irrespective of drug&rsquo;s physical property and amount of polymer, bio-adhesive strength of Xanthan gum was proved to be maximum followed by HPMC- 50 cps, Na-CMC and HPMC- 15 cps, whereas gelatin and PVP K-30 showed little or poor muco-adhesion. Xanthan gum, Na-CMC and HPMC based formulations showed nearly zero-order release; on the contrary PVP K-30 based formulation showed a burst release within one hour of dissolution.</p><p>DOI: <a href="http://dx.doi.org/10.3329/dujps.v10i1.10008">http://dx.doi.org/10.3329/dujps.v10i1.10008</a></p><p><em>DUJPS </em>2011; 10(1): 1-7</p> ER -