@article{Islam_Sutradhar_Chowdhury_Reza_2011, title={Effect of Hydrophobic Polymers on the Gastro Retention Time and <i>In vitro</i> Release of Ciprofloxacin HCl from Co-matrix Tablets}, volume={9}, url={https://www.banglajol.info/index.php/JPharma/article/view/7893}, DOI={10.3329/dujps.v9i2.7893}, abstractNote={&lt;p&gt;The present study was conducted to investigate the effect of different polymers on the release profile and bio-adhesive strength of a water soluble drug, ciprofloxacin HCl from different percentages of Eudragit RS PO and Kollidon SR based co-matrix tablets. Matrix formulations were prepared by direct compression method. The bioadhesive property was investigated in terms of retention time following &lt;em&gt;in vitro &lt;/em&gt;wash-off method. The concentrations of polymers were varied to investigate whether these variations can cause any change in release of ciprofloxacin HCl molecule and bio-adhesion property or not. In most of the cases it is found that Eudragit RS PO based co-matrix tablets release greater percentage of active drug and that bio-adhesive strength of Kollidon SR and xanthan gum based co-matrix tablets were significantly better. Finally it was revealed that xanthan gum provided optimum bioadhesion functioning as a synergist in co-matrices and comply the USP specification as a most suitable controlled release polymer.&lt;/p&gt; &lt;p&gt;&lt;strong&gt;Key words: &lt;/strong&gt;Gastro retention time; direct compression; ciprofloxacin HCl; Eudragit RS PO; Kollidon SR; xanthan gum.&lt;/p&gt; &lt;p&gt;DOI: http://dx.doi.org/10.3329/dujps.v9i2.7893&lt;/p&gt; &lt;p&gt;Dhaka Univ. J. Pharm. Sci. &lt;strong&gt;9&lt;/strong&gt;(2): 97-102, 2010 (December)&lt;/p&gt;}, number={2}, journal={Dhaka University Journal of Pharmaceutical Sciences}, author={Islam, Muhammad Shahidul and Sutradhar, Kumar Bishwajit and Chowdhury, Jakir Ahmed and Reza, Md Selim}, year={2011}, month={Jun.}, pages={97–102} }