Effect of Hydrophobic Polymers on the Gastro Retention Time and <i>In vitro</i> Release of Ciprofloxacin HCl from Co-matrix Tablets
Keywords:Gastro retention time, direct compression, ciprofloxacin HCl, Eudragit RS PO, Kollidon SR, xanthan gum
The present study was conducted to investigate the effect of different polymers on the release profile and bio-adhesive strength of a water soluble drug, ciprofloxacin HCl from different percentages of Eudragit RS PO and Kollidon SR based co-matrix tablets. Matrix formulations were prepared by direct compression method. The bioadhesive property was investigated in terms of retention time following in vitro wash-off method. The concentrations of polymers were varied to investigate whether these variations can cause any change in release of ciprofloxacin HCl molecule and bio-adhesion property or not. In most of the cases it is found that Eudragit RS PO based co-matrix tablets release greater percentage of active drug and that bio-adhesive strength of Kollidon SR and xanthan gum based co-matrix tablets were significantly better. Finally it was revealed that xanthan gum provided optimum bioadhesion functioning as a synergist in co-matrices and comply the USP specification as a most suitable controlled release polymer.
Key words: Gastro retention time; direct compression; ciprofloxacin HCl; Eudragit RS PO; Kollidon SR; xanthan gum.
Dhaka Univ. J. Pharm. Sci. 9(2): 97-102, 2010 (December)
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