Chemical and Biological Investigations of <i>Samanea saman</i> (Jacq.) Merr.

  • Faisol Ferdous Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Md Khalid Hossain Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Mohammad S Rahman Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Md Aslam Hossain Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Shaila Kabir Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Mohammad A Rashid Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka
Keywords: Samanea saman, Leguminosae, lupeol, epilupeol, antimicrobial activity, brine shrimp lethality bioassay

Abstract

Two compounds namely lupeol (1) and epilupeol (2) were isolated from n-hexane soluble fraction of crude methanol extract of the powdered whole plant of Samanea saman Merr. for the first time. The structures of the isolated compounds were established by extensive analyses of their high resolution NMR spectral data as well as co- TLC with authentic samples. In our preliminary screening, the n-hexane, carbon tetrachloride, and dichloromethane soluble fractions of the crude methanolic extract of S. saman were subjected to antimicrobial activity and brine shrimp lethality bioassay. The carbon tetrachloride soluble partitionate of the methanol extract exhibited mild to moderate antimicrobial activity and strong cytotoxicity having LC50 of 0.831μg/ml.

Key words: Samanea saman; Leguminosae; lupeol; epilupeol; antimicrobial activity; brine shrimp lethality bioassay.

DOI: http://dx.doi.org/10.3329/dujps.v9i2.7882

Dhaka Univ. J. Pharm. Sci. 9(2): 69-73, 2010 (December)

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Ferdous, F., Hossain, M., Rahman, M., Hossain, M., Kabir, S., & Rashid, M. (1). Chemical and Biological Investigations of <i>Samanea saman</i&gt; (Jacq.) Merr. Dhaka University Journal of Pharmaceutical Sciences, 9(2), 69-73. https://doi.org/10.3329/dujps.v9i2.7882
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