Synthesis and Cytotoxicity Study of Some Acetylisatins and Diazobiphenyls

  • Mohammad Mamun Hossain Department of Chemistry, Jahangirnagar University, Shaver, Dhaka
  • Sakanta Kumar Shaha Department of Chemistry, Jahangirnagar University, Shaver, Dhaka
  • Foysal Aziz Department of Chemistry, Jahangirnagar University, Shaver, Dhaka
  • Rahat Khan Department of Chemistry, Jahangirnagar University, Shaver, Dhaka
  • Md Mahabub Hossain Department of Chemistry, Jahangirnagar University, Shaver, Dhaka
Keywords: diazo-biphenyls, oxindoles, cytotoxicity, brine shrimp

Abstract

Nitrogenous heterocyclic compounds, oxindoles especially isatins and related heterocyles have excellent antifungal, anti-inflammatory, antimicrobial and anticancer activities. Oxindoles keto lactams (1-3) were synthesized according to modified Sandmayer method and their N-acetylated compounds (4-6) gave diazo-biphenyls (7-10) through ring cleavage and consequent cyclization reaction. Bis-amide (11), and Schiff-base (12) were synthesized from oxindoles respectively. The investigation of cytotoxicity of the synthesized compounds was carried out against brine shrimp lethality bioassay. In our present investigation some of the synthesized compounds such as halogen substituted acetylisatins (4-6) and the ring extended diazo-biphenyls, (7-10) have been shown to exhibit strong cytotoxic effect.

Key words: diazo-biphenyls; oxindoles; cytotoxicity; brine shrimp

DOI: 10.3329/dujps.v9i1.7423

Dhaka Univ. J. Pharm. Sci. 9(1): 1-6, 2010 (June)

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Hossain, M., Shaha, S., Aziz, F., Khan, R., & Hossain, M. (1). Synthesis and Cytotoxicity Study of Some Acetylisatins and Diazobiphenyls. Dhaka University Journal of Pharmaceutical Sciences, 9(1), 1-6. https://doi.org/10.3329/dujps.v9i1.7423
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