Preparation and Evaluation of <i>In Vitro</i> Release Kinetics of Theophylline Loaded Matrix Tablet Based on Eudragit NE 30 D and Eudragit RS 30 D

Authors

  • Mohammad Borhan Uddin Department of Pharmacy, North South University, Dhaka
  • Jakir Ahmed Chowdhury Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Kazi Rashidul Azam Department of Pharmacy, Northern University Bangladesh, Dhaka
  • Reza-ul Jalil Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Md Selim Reza Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka

DOI:

https://doi.org/10.3329/dujps.v8i2.6030

Keywords:

Eudragit RS 30 D, Eudragit NE 30 D, Theophylline, Matrix system, Controlled release

Abstract

In the present study efficiency of Eudragit NE 30 D and RS 30 D as matrix forming materials was investigated. It was found that theophylline loaded granules prepared with these two polymers could not sustain drug release for a significant period of time. However, compression of these granules into tablets retarded drug release for up to 7 hours. Release was similar with both of the polymers. Effects of fillers and rate modifiers on drug release have been assessed. Incorporation of lactose and starch caused substantial release of theophylline from both the polymeric systems. Avicel PH 101 intensified the retardation effect of both NE 30 D and RS 30 D on theophylline release. Hydrophobic excipients also show retardation of release from both NE 30 D and RS 30 D.

Key words: Eudragit RS 30 D; Eudragit NE 30 D; Theophylline; Matrix system; Controlled release

DOI: 10.3329/dujps.v8i2.6030

Dhaka Univ. J. Pharm. Sci. 8(2): 153-159, 2009 (December)

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How to Cite

Uddin, M. B., Chowdhury, J. A., Azam, K. R., Jalil, R.- ul, & Reza, M. S. (2010). Preparation and Evaluation of <i>In Vitro</i> Release Kinetics of Theophylline Loaded Matrix Tablet Based on Eudragit NE 30 D and Eudragit RS 30 D. Dhaka University Journal of Pharmaceutical Sciences, 8(2), 153–159. https://doi.org/10.3329/dujps.v8i2.6030

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