Antioxidant, Analgesic and CNS Depressant Activities of Commelina diffusa Burm. f.

Authors

  • Md Monirul Islam Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
  • Mashiur Rahman Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
  • Muhammad Asaduzzaman Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
  • Mohammad Shawkat Ali Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh

DOI:

https://doi.org/10.3329/dujps.v20i2.57166

Keywords:

Analgesic, antioxidant, CNS activity, Commelina diffusa, phytochemicals.

Abstract

Commelina diffusa Burm. f. is a member of Commelinaceae family, which is widely grown in crop land and treated as a weed. This plant has several important medicinal properties which have not been studied extensively. In this study, the crude powder of C. diffusa whole plant was extracted with 95% ethanol and different solvent fractions (n-hexane, chloroform and methanol) were prepared from the crude extract by solvent-solvent partitioning. All these plant samples were subjected to bioassays for evaluating the antioxidant, central analgesic, peripheral analgesic and CNS depressant activities. The crude extract and its methanol soluble fraction showed mild free DPPH scavenging property with IC50 values of 98.49- and 84.77-μg/ml, respectively as compared to the standard ascorbic acid (IC50 = 2.67 μg/ml). In the analgesic activity test, the n-hexane fraction of C. diffusa at doses of 200- and 400-mg/kg body weight exhibited significant (p<0.05) central analgesic activity (tail flick test) in mice. Similarly, all the test samples showed statistically significant (p<0.05) reduction in abdominal writhing induced by acetic acid. C. diffusa showed significant CNS depressant activity which was measured by ‘open field test’ and ‘hole cross test’. Considering the potential bioactivities, the plant materials can be further studied elaborately to explore the activities of the purified compounds to aid in future drug development.

Dhaka Univ. J. Pharm. Sci. 20(2): 159-166, 2021 (December)

Downloads

Download data is not yet available.
Abstract
60
PDF
54

Downloads

Published

2021-12-29

How to Cite

Islam, M. M., Rahman, M., Asaduzzaman, M. ., & Ali, M. S. (2021). Antioxidant, Analgesic and CNS Depressant Activities of Commelina diffusa Burm. f. Dhaka University Journal of Pharmaceutical Sciences, 20(2), 159–166. https://doi.org/10.3329/dujps.v20i2.57166

Issue

Section

Articles