Evaluation of Body Weight, Serum Lipid Profile, Glucose Homeostasis, Oxidative Stress and Hepatic Function in Healthy Mice Fed With Zinc Sulphate Supplementation

Authors

  • Md Atiqur Rahman Department of pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh
  • Mohammad Tohidul Amin Department of pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh
  • Sayema Arefin Department of Pharmacy, Mawlana Bhashani Science and Technology University, Tangail 1902, Bangladesh
  • Dipty Rani Bhowmik Department of pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh
  • Md Abdur Rahman Ripon Department of pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh
  • Mohammad Salim Hossain Department of pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh

DOI:

https://doi.org/10.3329/dujps.v20i1.54033

Keywords:

Zinc, Lipid Profile, Metabolic disease, Oxidative stress, Liver function.

Abstract

The present research study was designed to evaluate the effect of zinc supplementation on body weight, serum triglyceride, cholesterol, glucose homeostasis, oxidative stress, and hepatic function in mice. Mice were treated with zinc sulphate at an equivalent weight of 6.5 mg/kg-body weight elemental zinc for four weeks. Bodyweight, serum glucose, triglyceride, cholesterol, serum MDA, nitric oxide, vitamin C, and hepatic enzymes level were determined at the end of the study period. Data from this study showed that supplementation with zinc in mice maintained a balanced blood glucose homeostasis throughout the experimental period. Moreover, treatment with zinc showed a significant (p <0.05) decrease in serum triglyceride and cholesterol level along with a decrease in the body weight compared to control. Treatment with zinc significantly attenuated the rate of lipid peroxidation whereas increased the level of vitamin C and NO level. The protective effect of zinc on liver activity was observed. Treatment with zinc showed a strong negative association with serum total cholesterol (r= -0.934, p = 0.02), triglycerides level (r= -0.709, p = 0.05), and body weight (r= -0.899, p = 0.01). The present findings demonstrate that zinc supplementation can be helpful to maintain a glucose homeostasis, ameliorate hyperlipidemia, oxidative stress, and liver dysfunction. Therefore, zinc supplementation can be suggested to alleviate diseases associated with metabolic syndrome and oxidative stress.

Dhaka Univ. J. Pharm. Sci. 20(1): 59-66, 2021 (June)

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Published

2021-06-14

How to Cite

Rahman, M. A., Amin, M. T., Arefin, S., Bhowmik, D. R., Ripon, M. A. R., & Hossain, M. S. (2021). Evaluation of Body Weight, Serum Lipid Profile, Glucose Homeostasis, Oxidative Stress and Hepatic Function in Healthy Mice Fed With Zinc Sulphate Supplementation. Dhaka University Journal of Pharmaceutical Sciences, 20(1), 59–66. https://doi.org/10.3329/dujps.v20i1.54033

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