Comparison of Gastro Retention Time and <i>in vitro</i> Release Profile studies of Ciprofloxacin HCl from Co-matrix Tablets of Hydrophilic Polymers

Authors

  • Muhammad Shahidul Islam Department of Pharmacy, Stamford University Bangladesh,
  • Kazi Rashidul Azam Department of Pharmacy, Northern University Bangladesh
  • Jakir Ahmed Chowdury Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Md Selim Reza Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka

DOI:

https://doi.org/10.3329/dujps.v8i1.5338

Keywords:

Gastro retention time, Direct Compression, Ciprofloxacin HCl, Methocel K4M, Methocel K15M CR, Methocel K100LV, Xanthan gum

Abstract

Controlled release co-matrix tablets of Ciprofloxacin HCl were prepared with different types of bioadhesive
polymers e.g. Methocel K4M, Methocel K 15M CR and Methocel K 100LV, Povidone K-30, and Xanthan
gum. Tablets prepared by direct compression method were subjected to in-vitro drug dissolution study for 8 hours in
a simulated gastric fluid media using USP dissolution apparatus II with 50 rpm at 37±0.5ºC. The bio-adhesive
property was investigated in terms of retention time following in-vitro wash-off method. The concentrations of
polymers were varied to investigate whether these variations can cause any change in release of Ciprofloxacin HCl
molecule and bio-adhesion property or not. In most of the cases it is found that Methocel K4M and Methocel
K100LV based co-matrix tablets release greater percentage of active drug than Methocel K15M CR based co-matrix
tablets. Bio-adhesive strength of Methocel K15M CR and Xanthan gum based co-matrix tablets was proved to be
maximum followed by Methocel K4M and Xanthan gum based co-matrices. Whereas Methocel K100LV and
Xanthan gum based co-matrices showed little or poor muco-adhesion. Methocel K4M, K15M CR and Xanthan gum
based formulations showed nearly zero-order release, on the other hand Methocel K100LV and Xanthan gum based
formulation showed a burst release within one hour of dissolution. Finally it was revealed that Xanthan gum provided
optimum bio-adhesion functioning as a synergist in co-matrices and comply the USP specification as a most suitable
controlled release polymer.

Key words:
Gastro retention time; Direct Compression; Ciprofloxacin HCl; Methocel K4M; Methocel K15M CR;
Methocel K100LV; Xanthan gum.

DOI: 10.3329/dujps.v8i1.5338

Dhaka Univ. J. Pharm. Sci.
8(1): 67-73, 2009 (June)

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How to Cite

Islam, M. S., Azam, K. R., Chowdury, J. A., & Reza, M. S. (2010). Comparison of Gastro Retention Time and <i>in vitro</i> Release Profile studies of Ciprofloxacin HCl from Co-matrix Tablets of Hydrophilic Polymers. Dhaka University Journal of Pharmaceutical Sciences, 8(1), 67–73. https://doi.org/10.3329/dujps.v8i1.5338

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