Phytochemical and Biological Investigations of <i>Curcuma longa</i>

Authors

  • Mohammad GU Khan Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Kamrun Nahar Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Mohammad S Rahman Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Choudhury M Hasan Centre for Biomedical Research, University of Dhaka, Dhaka
  • Mohammad A Rashid Department of Pharmaceutical Chemistry and 2Centre for Biomedical Research, University of Dhaka, Dhaka

DOI:

https://doi.org/10.3329/dujps.v8i1.5334

Keywords:

Curcuma longa, Zingiberaceae, turmeronol-A, turmeronol-B, 2, 3, 5, 6-tetrahydroxy-arturmerone and 4- hydroxybisabola-2, 10-diene-9-one, antimicrobial, cytotoxicity

Abstract

Seven compounds, turmeronol-A (1), turmeronol-B (2), 3,4-dimethoxycinnamic acid (3), 4-hydroxy-
3-methoxycinnamic acid (4), 4-hydroxybenzaldehyde (5), 2,3,5,6-tetrahydroxyarturmerone (6) and 4-hydroxybisabola-
2,10-diene-9-one (7) have been isolated from the carbon tetrachloride soluble fraction of a methanol extract
of the rhizomes of Curcuma longa. Careful interpretation of the NMR data and comparison with turmeronol A (1)
allowed tentative identification of compound 6 as 2,3,5,6-tetrahydroxy-arturmerone, which appears to be a new
molecule. The n-hexane, carbon tetrachloride and chloroform extractives of the rhizomes when subjected to
antimicrobial screening and brine shrimp lethality bioassay demonstrated mild to moderate antimicrobial activity and
strong cytotoxicity with LC50 value 1.56 μg/ml.

Key words: Curcuma longa; Zingiberaceae; turmeronol-A; turmeronol-B; 2,3,5,6-tetrahydroxy-arturmerone and 4-
hydroxybisabola-2,10-diene-9-one; antimicrobial; cytotoxicity.

DOI: 10.3329/dujps.v8i1.5334

Dhaka Univ. J. Pharm. Sci. 8(1): 39-45, 2009 (June)

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How to Cite

Khan, M. G., Nahar, K., Rahman, M. S., Hasan, C. M., & Rashid, M. A. (2010). Phytochemical and Biological Investigations of <i>Curcuma longa</i>. Dhaka University Journal of Pharmaceutical Sciences, 8(1), 39–45. https://doi.org/10.3329/dujps.v8i1.5334

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