<i>In vitro</i> Release Kinetics Study of Ranolazine from Swellable Hydrophilic Matrix Tablets

Authors

  • Mohammad Nezab Uddin Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Ishtiaq Ahmed Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Monzurul Amin Roni Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Muhammad Rashedul Islam Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Mohammad Habibur Rahman Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Reza-ul Jalil Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka

DOI:

https://doi.org/10.3329/dujps.v8i1.5333

Keywords:

Ranolazine, Sustained release, Methocel E50 Premium LV, Methocel K100LV CR, Methocel K4M CR, Methocel K15M CR

Abstract

The objective of this study was to design oral sustained release matrix tablets of Ranolazine using
hydroxypropyl methylcellulose (HPMC) as the retardant polymer and to study the effect of formulation factors such
as polymer proportion and polymer viscosity on the release of drug. In vitro release studies were performed using
USP type II apparatus (paddle method) in 900 mL of 0.1N HCl at 100 rpm for 12 hours. The release kinetics was
analyzed using the zero-order, first order, Higuchi and Korsmeyer-Peppas equations to explore and explain the
mechanism of drug release from the matrix tablets. In vitro release studies revealed that the release rate decreased
with increase in polymer proportion and viscosity grade. Mathematical analysis of the release kinetics indicated that
the nature of drug release from the matrix tablets was dependent on drug diffusion and polymer relaxation and
therefore followed non-Fickian or anomalous release. The developed controlled release matrix tablets of Ranolazine
prepared with high viscosity HPMC extended release up to 12 hours.

Key words: Ranolazine; Sustained release; Methocel E50 Premium LV; Methocel K100LV CR; Methocel K4M CR;
Methocel K15M CR.

DOI: 10.3329/dujps.v8i1.5333

Dhaka Univ. J. Pharm. Sci. 8(1): 31-38, 2009 (June)

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How to Cite

Uddin, M. N., Ahmed, I., Roni, M. A., Islam, M. R., Rahman, M. H., & Jalil, R.- ul. (2010). <i>In vitro</i> Release Kinetics Study of Ranolazine from Swellable Hydrophilic Matrix Tablets. Dhaka University Journal of Pharmaceutical Sciences, 8(1), 31–38. https://doi.org/10.3329/dujps.v8i1.5333

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