Phytochemical and Biological Investigations of <i>Ixora lutea</i> Hutch.

Authors

  • Shapna Sultana Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Mohammad S Rahman Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Md Aslam Hossain Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka
  • Md Khalid Hossain Centre for Biomedical Research, University of Dhaka, Dhaka
  • Mohammad A Rashid Department of Pharmaceutical Chemistry and 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka

DOI:

https://doi.org/10.3329/dujps.v8i1.5331

Keywords:

Ixora lutea, rubiaceae, lupeol, stigmasterol, antioxidant activity, brine shrimp lethality bioassay, antimicrobial

Abstract

Two triterpenoids, lupeol (1) and stigmasterol were isolated from the petroleum ether soluble fraction
of the methanolic extract of Ixora lutea Hutch. In our preliminary screening, the petroleum ether, carbon
tetrachloride, chloroform soluble fractions of methanol extract of the leaves and stem were subjected to antioxidant,
antimicrobial and brine shrimp lethality bioassay. All of the fractions showed moderate to potent antioxidant activity,
of which the chloroform soluble fraction demonstrated the strongest antioxidant activity with the IC50 value of 3.0
μg/ml. In case of antimicrobial screening, all extractives showed mild growth inhibitory activity. However, in the
brine shrimp lethality bioassay, the petroleum ether soluble fraction was found to be most cytotoxic among the
partitionates having LC50 value 0.938 μg/ml.

Key words: Ixora lutea; rubiaceae; lupeol; stigmasterol; antioxidant activity; brine shrimp lethality bioassay;
antimicrobial.

DOI: 10.3329/dujps.v8i1.5331

Dhaka Univ. J. Pharm. Sci.
8(1): 17-21, 2009 (June)

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How to Cite

Sultana, S., Rahman, M. S., Hossain, M. A., Hossain, M. K., & Rashid, M. A. (2010). Phytochemical and Biological Investigations of <i>Ixora lutea</i> Hutch. Dhaka University Journal of Pharmaceutical Sciences, 8(1), 17–21. https://doi.org/10.3329/dujps.v8i1.5331

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