Characterization of Chitosan Obtained from Snail Shell (Achatina fulica) and its Excipient Potentials in Metronidazole Tablet Formulation

Authors

  • Oluyemisi Adebowale Bamiro Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Nigeria
  • Aishat Oyinkansola Salisu Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Nigeria
  • Ese Mary Iyere Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Nigeria
  • Olatundun Atoyegbe Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Nigeria
  • Olutayo Ademola Adeleye Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Nigeria
  • Lateef Gbenga Bakre Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Nigeria

DOI:

https://doi.org/10.3329/dujps.v19i2.50855

Keywords:

Chitosan, Achatina fulica, Disintegrant, Binder, Metronidazole, Dissolution

Abstract

The aim of the work was to characterize chitosan extracted from snail shell and evaluate its use as a disintegrant and binder in metronidazole tablet formulation in comparison with standard chitosan (SC). The mechanical properties were assessed using crushing strength and friability, while the release properties were assessed using disintegration and dissolution times. The extracted chitosan (EC) was crystalline in nature and the scanning electron microscopy (SEM) showed polygonal particles with rough surface. The moisture and swelling capacity was 1.80% and 15.00%, respectively. The densities and flow properties were significantly (p<0.05) higher than those of the SC. As a binder, the crushing strength of formulations containing EC was higher than SC, but both formulation failed friability test. There was significant difference between the disintegration times of the metronidazole formulations containing EC and SC as a disintegrant. The result showed that EC is more effective as a binder in tablet formulations.

Dhaka Univ. J. Pharm. Sci. 20(1): 31-39, 2021 (June)

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Published

2021-06-20

How to Cite

Bamiro, O. A., Salisu, A. O., Iyere, E. M., Atoyegbe, O., Adeleye, O. A., & Bakre, L. G. (2021). Characterization of Chitosan Obtained from Snail Shell (Achatina fulica) and its Excipient Potentials in Metronidazole Tablet Formulation. Dhaka University Journal of Pharmaceutical Sciences, 20(1), 31–39. https://doi.org/10.3329/dujps.v19i2.50855

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