Synthesis and Antidepressant Activity of Pyrazoline Derivatives

Authors

  • BC Revanasiddappa Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences of Nitte - Deemed to be University, Paneer, Deralakatte Mangalore-575 018, Karnataka, India
  • M Vijay Kumar Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences of Nitte - Deemed to be University, Paneer, Deralakatte Mangalore-575 018, Karnataka, India
  • Hemanth Kumar Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences of Nitte - Deemed to be University, Paneer, Deralakatte Mangalore-575 018, Karnataka, India

DOI:

https://doi.org/10.3329/dujps.v19i2.50634

Keywords:

Chalcones, pyrazolines, semicarbazide, tail suspension test, forced swimming test.

Abstract

In the present study a series of substituted pyrazolines (3a-f) has been synthesized by reacting chalcones (2a-f) and semicarbazide (1) in methanol medium. All the title compounds were assessed for their in-vivo anti-depressant activity by tail suspension test (TST) and forced swimming test (FST) methods. Compound 3a was found to exhibit moderate antidepressant activity in comparison to standard Imipramine. Newly synthesized compounds were characterized by mass (MS), 1H-NMR and infrared (IR) spectral analytical data.

Dhaka Univ. J. Pharm. Sci. 19(2): 179-184, 2020 (December)

Downloads

Download data is not yet available.
Abstract
276
PDF
407

Downloads

Published

2020-12-10

How to Cite

Revanasiddappa, B., Kumar, M. V., & Kumar, H. (2020). Synthesis and Antidepressant Activity of Pyrazoline Derivatives. Dhaka University Journal of Pharmaceutical Sciences, 19(2), 179–184. https://doi.org/10.3329/dujps.v19i2.50634

Issue

Section

Articles