In vitro Complexation of Olmesartan Medoxomil with Dapagliflozin, Vildagliptin and Metformin

  • Fahima Aktar Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka1000, Bangladesh
  • Md Zakir Sultan Centre for Advanced Research in Sciences, University of Dhaka, Dhaka-1000, Bangladesh
  • Mohammad A Rashid Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka1000, Bangladesh
Keywords: Drug-drug interaction, olmesartan medoxomil, dapagliflozin, vildagliptin, metformin, TLC, HPLC, FTIR, DSC, TGA.

Abstract

Drug-drug interactions have been a serious concern for pharmacokinetics, pharmacodynamics and pharmacological profiles of therapeutic agents. The aim of this study was to carry out interactions of olmesartan medoxomil with dapagliflozin, vildagliptin and metformin, which were confirmed by TLC, HPLC and FT-IR. The newly formed complexes showed characteristic thermochemical properties in differential scanning calorimetry (DSC) and thermo gravimetric analysis (TGA). In TLC, three spots from the three complexes were found to be different from their precursor drugs. In HPLC chromatograms, the Rt (retention time) of the pure olmesartan medoxomil, dapagliflozin, vildagliptin and metformin were found to be different from their respective complexes. The FT-IR spectra obtained for drug-drug interactions were seen to demonstrate new pattern of peaks compared to pure drugs. The DSC and TGA thermograms of olmesartan medoxomil, dapagliflozin, vildagliptin and metformin were also found to be different from their complexes. All these variations from parent compounds indicated the formation of new complexes.

Dhaka Univ. J. Pharm. Sci. 18(2): 271-180, 2019 (December)

Downloads

Download data is not yet available.
Abstract
279
PDF
226
Published
2019-12-12
How to Cite
Aktar, F., Sultan, M. Z., & Rashid, M. A. (2019). In vitro Complexation of Olmesartan Medoxomil with Dapagliflozin, Vildagliptin and Metformin. Dhaka University Journal of Pharmaceutical Sciences, 18(2), 271-280. https://doi.org/10.3329/dujps.v18i2.44467
Section
Articles