Evaluation of Antioxidant and Cytotoxic Activities of Aerial Parts of Adiantum capillus-veneris L. Growing in Bangladesh

  • Suvash Chandra Roy 1Department of Pharmacology, Institute of Applied Health Sciences, University of Science and Technology Chittagong, Chittagong-4202, Bangladesh
  • BK Sajeeb Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka Dhaka-1000, Bangladesh
  • Md Abdul Muhit Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka Dhaka-1000, Bangladesh
  • Sitesh C Bachar Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
Keywords: Antioxidant, cytotoxicity, Adiantum capillus-veneris L., fractionation, bioactivity

Abstract

The present study evaluated the antioxidant and cytotoxic activities of methanolic extract of aerial parts of Adiantum capillus-veneris L. and its different solvent fractions. The in vitro antioxidant activity was assessed by using 2,2’-diphenyl-1-picrylhydrazyl (DPPH) radicals. The analysis revealed that ethyl acetate soluble fraction had the highest DPPH radicals scavenging property with IC50 value of 1.05 μg/ml as compared to positive control ascorbic acid (IC50 = 1.34 μg/ml). In addition, ex vivo cytotoxicity assay of A. capillus-veneris L. extract and its different fractions were performed against HELA cells line where 5-Fluorouracil was used as positive control. The result demonstrated that ethyl acetate and n-hexane soluble fractions showed prominent cytotoxicity with IC50 value of 5.68 μg/ml and 17.15 μg/ml, respectively. The study affirmed that superior antioxidant and cytotoxic activities were shown by ethyl acetate soluble fraction of methanolic extract of aerial parts of A. capillus-veneris L. growing in Bangladesh which indicate the presence of bioactive phytoconstituents in the extractives.

Dhaka Univ. J. Pharm. Sci. 18(2): 217-222, 2019 (December)

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Abstract
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Published
2019-09-22
How to Cite
Roy, S., Sajeeb, B., Muhit, M. A., & Bachar, S. C. (2019). Evaluation of Antioxidant and Cytotoxic Activities of Aerial Parts of Adiantum capillus-veneris L. Growing in Bangladesh. Dhaka University Journal of Pharmaceutical Sciences, 18(2), 217-222. https://doi.org/10.3329/dujps.v18i2.43264
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Articles