Synthesis, Antibacterial and Antifungal Evlaution of Novel Pyrazoline Derivatives

  • BC Revanasiddappa Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences of Nitte -Deemed to be University, Paneer, Deralakatte Mangalore-575 018, Karnataka
  • MS Jisha Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences of Nitte -Deemed to be University, Paneer, Deralakatte Mangalore-575 018, Karnataka
  • M Vijay Kumar Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences of Nitte -Deemed to be University, Paneer, Deralakatte Mangalore-575 018, Karnataka
  • Hemanth Kumar Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences of Nitte -Deemed to be University, Paneer, Deralakatte Mangalore-575 018, Karnataka
Keywords: Chalcones, pyrazolines, antibacterial activity, antifungal activity, guanicol hydrazide

Abstract

A new series of chalcones (2a-j) were prepared by reacting substituted aldehydes and substituted ketones in alcohol medium in presence of NaOH. The chalcones underwent selective cyclization with guanicol hydrazide (1) in glacial acetic acid medium to yield the title compounds 1,3,5-trisubstituted pyrazolines (3a-j). The new compounds were characterized on the basis of 1H-NMR, IR and mass spectral data. All the newly synthesized compounds were evaluated for their in-vitro antibacterial and antifungal activities. Some of the tested compounds 3a and 3e showed good activity against bacterial strains and compounds 3d and 3h revealed good activity against fungal strains.

Dhaka Univ. J. Pharm. Sci. 17(2): 221-226, 2018 (December)

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Author Biographies

BC Revanasiddappa, Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences of Nitte -Deemed to be University, Paneer, Deralakatte Mangalore-575 018, Karnataka

Department of Pharmaceutical Chemistry

MS Jisha, Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences of Nitte -Deemed to be University, Paneer, Deralakatte Mangalore-575 018, Karnataka

Department of Pharmaceutical Chemistry

M Vijay Kumar, Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences of Nitte -Deemed to be University, Paneer, Deralakatte Mangalore-575 018, Karnataka

Department of Pharmaceutical Chemistry

Hemanth Kumar, Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences of Nitte -Deemed to be University, Paneer, Deralakatte Mangalore-575 018, Karnataka

Department of Pharmaceutical Chemistry

Published
2018-12-04
How to Cite
Revanasiddappa, B., Jisha, M., Kumar, M., & Kumar, H. (2018). Synthesis, Antibacterial and Antifungal Evlaution of Novel Pyrazoline Derivatives. Dhaka University Journal of Pharmaceutical Sciences, 17(2), 221-226. https://doi.org/10.3329/dujps.v17i2.39179
Section
Articles