Clerodendrum inerme (L.) Gaertn. Extract Exerts Anticancer Activity on Lung Cancer Cells

Authors

  • Mahendra Kumar Chouhan Department of Pharmaceutical Biotechnology, College of Pharmacy, KLE Academy of Higher Education and Research (Deemed-to-be University) Belagavi, Karnataka
  • Pramod Jayadevappa Hurakadle Department of Pharmaceutical Biotechnology, College of Pharmacy, KLE Academy of Higher Education and Research (Deemed-to-be University) Belagavi, Karnataka
  • Harsha Vasudev Hegde ICMR- National Institute of Traditional Medicine (Formerly Regional Medical Research Center), Belagavi Karnataka

DOI:

https://doi.org/10.3329/dujps.v17i2.39175

Keywords:

Clerodendrum inerme, RBC aggregation, MTT, Cytotoxicity

Abstract

Cancer is the leading cause of death word wide. Recently there are no new drugs for safe and efficient treatment. Clerodendrum inerme (L.) Gaertn. (Verbenaceae) plant is being used by the ethnic people for cancer treatment. In this study, cytotoxic and antiproliferative potential of hydroalcoholic (methanol and water; 70:30 v/v) extract of C. inerme were evaluated. Various anticancer investigations performed like, lung cancer cell A-549 culture, dye exclusion assay, MTT assay, morphological changes and compatibility with RBC, confirmed the presence of the moiety that have the cytotoxic and antiproliferative potential. Compatibility with RBC was observed, when treated with standard drug doxorubicin, and hydroalcoholic extract of C. inerme at 259.5 μg/ml concentration (IC50). In addition, the same treatment reveled, decrease in cytotoxic efficacy and cell viability against lung cancer cells. Furthermore, change in the cell morphology also suggesting potent antitumor properties of C. inerme.

Dhaka Univ. J. Pharm. Sci. 17(2): 191-196, 2018 (December)

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Author Biographies

Mahendra Kumar Chouhan, Department of Pharmaceutical Biotechnology, College of Pharmacy, KLE Academy of Higher Education and Research (Deemed-to-be University) Belagavi, Karnataka

Department of Pharmaceutical Biotechnology

Pramod Jayadevappa Hurakadle, Department of Pharmaceutical Biotechnology, College of Pharmacy, KLE Academy of Higher Education and Research (Deemed-to-be University) Belagavi, Karnataka

Department of Pharmaceutical Biotechnology

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Published

2018-12-04

How to Cite

Chouhan, M. K., Hurakadle, P. J., & Hegde, H. V. (2018). Clerodendrum inerme (L.) Gaertn. Extract Exerts Anticancer Activity on Lung Cancer Cells. Dhaka University Journal of Pharmaceutical Sciences, 17(2), 191–196. https://doi.org/10.3329/dujps.v17i2.39175

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Articles