Studies of Degradation Kinetics of a 5-HT3 Antagonist, Ramosetron Hydrochloride: Effects of Temperature

Authors

  • Md Mokaram Hossain Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Reza ul Jalil Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Mohammad A Rashid Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000

DOI:

https://doi.org/10.3329/dujps.v17i2.39172

Keywords:

Degradation kinetics, reaction rate constant, activation energy, half-life, shelf-life

Abstract

Ramosetron hydrochloride is the hydrochloride salt of ramosetron, a selective serotonin (5-HT3) receptor antagonist with potential antiemetic activity. Upon administration, ramosetron selectively binds to and blocks the activity of 5-HT subtype 3 (5-HT3) receptors located in the vagus nerve terminal and the vomiting center of central nervous system (CNS), suppressing chemotherapy-induced nausea and vomiting. Degradation of Ramosetron HCl was conducted with 0.1N NaOH at 60°C, 70°C and 80°C to study the reaction kinetics. The reaction rate constants (k) for degradation at 60°C, 70°C and 80°C were -2.2680 molL-1s-1 , -3.3714 molL-1s-1 and -5.3686 molL-1s-1 for zero order and -1.05 x 10-2s-1, -1.60 x 10-2s-1 and -2.70 x 10-2s-1 for first order kinetics, respectively. The activation energy of Ramosetron HCl was found as 10.05 kcalmol-1 by using Arrhenius equation.

Dhaka Univ. J. Pharm. Sci. 17(2): 167-173, 2018 (December)

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Author Biographies

Md Mokaram Hossain, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000

Department of Pharmaceutical Chemistry

Reza ul Jalil, Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000

Department of Pharmaceutical Technology

Mohammad A Rashid, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000

Department of Pharmaceutical Chemistry

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Published

2018-12-04

How to Cite

Hossain, M. M., Jalil, R. ul, & Rashid, M. A. (2018). Studies of Degradation Kinetics of a 5-HT3 Antagonist, Ramosetron Hydrochloride: Effects of Temperature. Dhaka University Journal of Pharmaceutical Sciences, 17(2), 167–173. https://doi.org/10.3329/dujps.v17i2.39172

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Articles