Synthesis and Antioxidant Activity of Some Novel Benzimidazole Derivatives

Authors

  • Nilima Karmaker Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Dilshad Noor Lira Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Biplab Kumar Das Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Uttom Kumar Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Abu Shara Shamsur Rouf Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000

DOI:

https://doi.org/10.3329/dujps.v16i2.35263

Keywords:

Benzimidazole, synthesis, antioxidant activity, DPPH, BHT

Abstract

A series of 2-substituted-5-methylbenzimidazole derivatives (3a-e) were synthesized by reacting   4-methyl-1,2-phenylenediamine (1) with a number of p-substituted benzaldehydes (2a-e) in moderate yields (25.51-   40.21%). The synthesized compounds (3a-e) were characterized by spectroscopic data and were evaluated for   antioxidant activity using DPPH free radical scavenging assay. The compounds showed significant antioxidant   activity having IC50 value of 1.054-19.05 μg/ml as compared to the standard BHT (26.96 μg/ml).

Dhaka Univ. J. Pharm. Sci. 16(2): 245-249, 2017 (December)

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Published

2018-01-10

How to Cite

Karmaker, N., Lira, D. N., Das, B. K., Kumar, U., & Rouf, A. S. S. (2018). Synthesis and Antioxidant Activity of Some Novel Benzimidazole Derivatives. Dhaka University Journal of Pharmaceutical Sciences, 16(2), 245–249. https://doi.org/10.3329/dujps.v16i2.35263

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Articles