Chemical and Biological Investigations of Cerbera odollam Gaertn

Authors

  • Monica Sharfin Rahman Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka- 1000
  • Adnan Faisal Uttara Adhunic Medical College, Uttara, Dhaka
  • Choudhury Mahmood Hasan Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka- 1000
  • Monira Ahsan Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka- 1000
  • Mohammad Mehedi Masud Uttara Adhunic Medical College, Uttara, Dhaka

DOI:

https://doi.org/10.3329/dujps.v16i2.35255

Keywords:

Cerbera odollam, triticusterol, antioxidant activity, cytotoxicity, antimicrobial activity, thrombolytic activity, membrane stabilizing activity

Abstract

The present article describes the isolation and characterization of secondary metabolites from the leaves of Cerbera odollam as well as bioactivities of the crude methanolic extract and its petroleum ether (PE), carbon tetrachloride (CTC), chloroform (CF) and aqueous (AQ) soluble fractions. In this investigation, successive chromatographic separation and purification yielded β-amyrin (CO-01), lupeol (CO-02), β-sitostenone (CO-03) and triticusterol (CO-04). The study also indicated the antioxidant, cytotoxic, antimicrobial, membrane stabilizing activities and poor thrombolytic activities. Thus, the present study endeavors to provide scientific basis to establish Cerbera odollam as a potential medicinal plant.

Dhaka Univ. J. Pharm. Sci. 16(2): 179-186, 2017 (December)

Downloads

Download data is not yet available.
Abstract
1744
PDF
1882

Downloads

Published

2018-01-10

How to Cite

Rahman, M. S., Faisal, A., Hasan, C. M., Ahsan, M., & Masud, M. M. (2018). Chemical and Biological Investigations of Cerbera odollam Gaertn. Dhaka University Journal of Pharmaceutical Sciences, 16(2), 179–186. https://doi.org/10.3329/dujps.v16i2.35255

Issue

Section

Articles