Studies of Anti-arrhythmic and Hypercholesterolemic Activities of Ayurvedic Preparation ‘Lauhasab’ in Rat Model

Authors

  • Refaya Rezwan Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Sharmin Zafar Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Abu Asad Chowdhury Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Shaila Kabir Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Mohammad Shah Amran Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Mohammad Abdur Rashid Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry Faculty of Pharmacy, University of Dhaka, Dhaka-1000

DOI:

https://doi.org/10.3329/dujps.v16i1.33387

Keywords:

ECG, digoxin, anti-arrhythmic, lipid, herbal remedy

Abstract

Lauhasab, an Ayurvedic preparation, is widely used in anemia and cardiovascular diseases. Despite its claim as a cardio-tonic there is paucity of studies on pharmacological activities and toxicities. In this study, the anti-arrhythmic effect and impact on lipid profile were evaluated. Rats were pretreated with 0.28 and 2.8 ml/kg body weight of Lauhasab for 35 days and electrocardiographic tracings were recorded and analyzed to determine heart rate and occurrence of arrhythmia. Electrocardiogram recorded before digoxin administration showed significant decrease in mean heart rate along with longer duration of bradycardia than in digoxin control group after 35 days of chronic pretreatment with both doses of Lauhasab. In animal experiments, various arrhythmias were observed after intraperitoneal injection of digoxin. Lauhasab decreased the duration and delayed onset of time of various arrhythmias. It showed significant increase in cholesterol and triglyceride levels in a dose dependent manner. It can be concluded that Lauhasab possesses significant anti-arrhythmic activity against digoxin-induced arrhythmia. It also revealed hyperlipidemic effects.

Dhaka Univ. J. Pharm. Sci. 16(1): 95-105, 2017 (June)

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Author Biography

Refaya Rezwan, Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry Faculty of Pharmacy, University of Dhaka, Dhaka-1000



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Published

2017-07-30

How to Cite

Rezwan, R., Zafar, S., Chowdhury, A. A., Kabir, S., Amran, M. S., & Rashid, M. A. (2017). Studies of Anti-arrhythmic and Hypercholesterolemic Activities of Ayurvedic Preparation ‘Lauhasab’ in Rat Model. Dhaka University Journal of Pharmaceutical Sciences, 16(1), 95–105. https://doi.org/10.3329/dujps.v16i1.33387

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