Antibacterial and Cytotoxic Constituents from Bridelia verrucosa Haines Growing in Bangladesh

Authors

  • Adeeba Anjum Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Md Zakir Sultan Centre for Advanced Research in Sciences, University of Dhaka, Dhaka-1000
  • Choudhury M Hasan Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Mohammad A Rashid Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000

DOI:

https://doi.org/10.3329/dujps.v16i1.33383

Keywords:

Bridelia verrucosa, triterpenes, lignans, steroids, antimicrobial, cytotoxicity, free radical scavenging

Abstract

Fractionation and purification of methanolic extract of stem bark of the Bridelia verrucosa growing in Bangladesh afforded glochidonol (1), brassicasterol (2), friedelin (3), 5?-24S-ethylchoestane-3?-ol (4), stigmasterol (5), ketooleanane (6), 5-5'-dihydroxy sesamine (7) and pinoresinol (8). Compounds 1, 2, 3, 4, 6 and 8 are the first report of their isolation from the plant while compound 7 appear to be a new isolate from natural source. The isolated compounds exhibited cytotoxic activity against brine shrimp nauplii having significant LC50 and LC90 values and moderate to strong antimicrobial activity against 13 Gram positive and Gram negative bacterial strains and 3 fungi. Compound 8 showed highest inhibition of growth of microorganisms with zone of inhibition of 16.7 mm against Shigella dysenteriae. Compounds 1-4 and 6-8 also revealed moderate free radical scavenging activity, in DPPH assay.

Dhaka Univ. J. Pharm. Sci. 16(1): 61-68, 2017 (June)

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Author Biography

Adeeba Anjum, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000



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Published

2017-07-30

How to Cite

Anjum, A., Sultan, M. Z., Hasan, C. M., & Rashid, M. A. (2017). Antibacterial and Cytotoxic Constituents from Bridelia verrucosa Haines Growing in Bangladesh. Dhaka University Journal of Pharmaceutical Sciences, 16(1), 61–68. https://doi.org/10.3329/dujps.v16i1.33383

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Articles