Determination of ?iroctone Olamine (Octopirox) in Bulk by UV Spectrophotometric Method

Authors

  • Lyudmyla M Antypenko Organic and Bioorganic Chemistry Department, Zaporizhzhya State Medical University, 26, Mayakovsky Avenue, Zaporizhzhya, 69035
  • Vitaliy A Solodovnyk Technology of Drugs Department, Zaporizhzhya State Medical University, 26, Mayakovsky Avenue Zaporizhzhya, 69035

DOI:

https://doi.org/10.3329/dujps.v16i1.33380

Keywords:

Octopirox, validation, UV-spectrophotometry

Abstract

A simple and low-cost UV-spectrophotometric method has been developed and validated for the quantification of Octopirox in bulk. The linearity was found at 307 ± 1 nm in 10-50 ?g/ml solution of ethanol-water (1:3, v:v) with r2 = 0.99. The limit of detection was found to be 1.18 µg/ml, while the limit of quantification was 3.58 µg/ml. The method was validated for linearity, accuracy, precision, range, ruggedness and robustness.

Dhaka Univ. J. Pharm. Sci. 16(1): 37-42, 2017 (June)

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Author Biography

Lyudmyla M Antypenko, Organic and Bioorganic Chemistry Department, Zaporizhzhya State Medical University, 26, Mayakovsky Avenue, Zaporizhzhya, 69035



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Published

2017-07-30

How to Cite

Antypenko, L. M., & Solodovnyk, V. A. (2017). Determination of ?iroctone Olamine (Octopirox) in Bulk by UV Spectrophotometric Method. Dhaka University Journal of Pharmaceutical Sciences, 16(1), 37–42. https://doi.org/10.3329/dujps.v16i1.33380

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