Design and Development of Bi-layered Sustained Release Azithromycin Tablets

  • Muhammad Rashedul Islam Department of Pharmaceutical Technology, University of Dhaka, Dhaka-1000
  • Md Mizanur Rahman Moghal Department of Pharmacy, MawlanaBhashani Science and Technology University, Santosh, Tangail-1902
  • FM Shah Noman Ul Bari Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814
  • Elias Al Mamun Department of Pharmaceutical Technology, University of Dhaka, Dhaka-1000
Keywords: Azithromycin, bilayer tablet, HPMC, Carbopol, sustained release

Abstract

The objective of the current study was to develop a bilayer tablet of Azithromycin containing both immediate and sustained layer and evaluate the effect of formulation variables on drug release. Thirty different formulations (F-1 to F-30) were prepared by direct compression. When the fraction of polymer was increased from 5.55% to 10%, the rate of drug release was found to be slower. Maximum release of Azithromycin was from F-11 (within 8 hours), which contained 50 mg (5.55%) of HPMC 50 cps. Slowest release was observed from F-30 containing 90 mg (10%) of Carbopol 974 P. The IR spectral analysis revealed that all rate regarding agents and excipients used in this study are compatible with the active Azithromycin.

Dhaka Univ. J. Pharm. Sci. 15(2): 227-234, 2016 (December)

Downloads

Download data is not yet available.
Abstract
528
PDF
355

Author Biography

Muhammad Rashedul Islam, Department of Pharmaceutical Technology, University of Dhaka, Dhaka-1000


Published
2017-01-02
How to Cite
Islam, M. R., Moghal, M. M., Bari, F. S., & Mamun, E. (2017). Design and Development of Bi-layered Sustained Release Azithromycin Tablets. Dhaka University Journal of Pharmaceutical Sciences, 15(2), 227-234. https://doi.org/10.3329/dujps.v15i2.30942
Section
Articles