Effect of Serum Trace Elements, Macro-minerals and Antioxidants in Acne Vulgaris Patients: A Case-Control Study

Authors

  • Salma Ahmed Department of Pharmacy, Northern University Bangladesh, Dhaka-1205
  • Rubaiya Ali Department of Dermatology and Venereology, Ad-Din Women?s Medical College, Dhaka- 1217
  • Md Reazul Islam Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Md Anamul Hoque Department of Pharmacy, Northern University Bangladesh, Dhaka-1205
  • Abul Hasnat Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Zabun Nahar Department of Pharmacy, Northern University Bangladesh, Dhaka-1205

DOI:

https://doi.org/10.3329/dujps.v15i2.30940

Keywords:

Trace elements, antioxidants, macro-minerals, acne vulgaris

Abstract

Acne vulgaris is a chronic skin disease with multifaceted cause. The exact etiology and pathogenesis of acne are yet to be established completely and various causative factors are considered as pathogenic mechanisms in the development of this disorder. We designed a study to determine the extent of serum trace elements, macrominerals and antioxidants in patients with acne, and thereby, to find the pathophysiological correlations, if any. Serum trace elements and macro-minerals were determined by flame atomic absorption spectroscopy. RP-HPLC was used to quantify antioxidants. Significantly (p<0.05) decreased level of zinc (1.90±0.06 vs. 2.17±0.09 mg/L), calcium (115.64±4.84 vs. 197.05±7.11 mg/L) and vitamin A (0.2±0.06 vs. 0.86±0.26 ?mol/L) was found in patient when compared with the corresponding controls. This investigation suggests a commendable association between the pathogenesis of acne vulgaris with the reduced level of zinc, calcium and vitamin A which could well be used as a diagnostic tool for acne vulgaris.

Dhaka Univ. J. Pharm. Sci. 15(2): 215-220, 2016 (December)

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Author Biography

Salma Ahmed, Department of Pharmacy, Northern University Bangladesh, Dhaka-1205



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Published

2017-01-02

How to Cite

Ahmed, S., Ali, R., Islam, M. R., Hoque, M. A., Hasnat, A., & Nahar, Z. (2017). Effect of Serum Trace Elements, Macro-minerals and Antioxidants in Acne Vulgaris Patients: A Case-Control Study. Dhaka University Journal of Pharmaceutical Sciences, 15(2), 215–220. https://doi.org/10.3329/dujps.v15i2.30940

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