Bioactivities and Chemical Profiling of Sesbania grandiflora (L.) Poir. Leaves Growing in Bangladesh

  • Farhina Rahman Laboni Department of Pharmacy, World University of Bangladesh, 151/8 Green road, Dhaka-1205
  • Samira Karim Department of Pharmacy, World University of Bangladesh, 151/8 Green road, Dhaka-1205
  • Jalal Uddin Department of Pharmacy, World University of Bangladesh, 151/8 Green road, Dhaka-1205
  • Zubair Khalid Labu Department of Pharmacy, World University of Bangladesh, 151/8 Green road, Dhaka-1205
Keywords: Sesbania grandiflora, thrombolytic, membrane stabilizing

Abstract

The ethanolic extract of leaves of Sesbania grandiflora and their organic and aqueous soluble partitioning substances were evaluated for thrombolytic and membrane stabilizing potentials in vitro. In thrombolytic assay, among all partitionates, the ethyl acetate soluble fraction showed highest percent of clot lysis (59.57%) as compared to 69.23% and 3.07% exhibited by the standard streptokinase and water (negative control), respectively. With respect to the membrane stabilizing activity, ethyl acetate soluble fractions of S. grandiflora also profoundly inhibited the hemolysis of erythrocytes induced by osmosis (64.30 ± 0.64%) and heat (57.21 ± 0.69%), respectively. In contrast, standard acetyl salicylic acid resulted in 70.12 ± 26% inhibition of osmotically-induced hemolysis and slightly higher level of protection against heat-induced hemolysis (73.90 ± 0.29%). The ethanol extract of leaves of S. grandiflora revealed significant percentage of thrombolytic and membrane stabilizing activities.

Dhaka Univ. J. Pharm. Sci. 15(2): 173-176, 2016 (December)

Downloads

Download data is not yet available.
Abstract
669
PDF
397

Author Biography

Farhina Rahman Laboni, Department of Pharmacy, World University of Bangladesh, 151/8 Green road, Dhaka-1205


Published
2017-01-02
How to Cite
Laboni, F., Karim, S., Uddin, J., & Labu, Z. (2017). Bioactivities and Chemical Profiling of Sesbania grandiflora (L.) Poir. Leaves Growing in Bangladesh. Dhaka University Journal of Pharmaceutical Sciences, 15(2), 173-176. https://doi.org/10.3329/dujps.v15i2.30932
Section
Articles