Fabrication and in vitro Evaluation of Allopurinol Fast Dissolving Tablets Using Croscarmellose Sodium, Sodium Starch Glycolate and Crospovidone as Superdisintegrants

Authors

  • Md Mizanur Rahman Moghal Department of Pharmacy, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902
  • Sujit Chandra Mazumder Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814
  • Dilshad Noor Lira Department of Pharmaceutical Technology, University of Dhaka, Dhaka-1000
  • Abu Shara Shamsur Rouf Department of Pharmaceutical Technology, University of Dhaka, Dhaka-1000

DOI:

https://doi.org/10.3329/dujps.v15i1.29199

Keywords:

Fast dissolving tablets, Allopurinol, Superdisintegrants, Disintegration time

Abstract

The main objective of the study was to formulate fast dissolving tablets of allopurinol to achieve better dissolution rate and further improving the bioavailability to provide a quick onset of action. Nine formulations of fast dissolving tablets of allopurinol were prepared by direct compression technique using croscarmellose sodium (Group A), sodium starch glycolate (Group B) and crospovidone (Group C) as superdisintegrants in different concentrations. All formulations showed satisfactory mechanical strength, uniform weight & drug content, and lesser wetting time & dispersion time. In vitro disintegration time, dispersion time, wetting time of all nine formulations were obtained from 11.67±0.88 to 40.67±1.20 seconds, 32.67±0.88 to 65.33±1.45 seconds and 21.67±0.33 to 50.00±1.53 seconds respectively. Amongst all formulations, formulation F-9 prepared by 4.17% crospovidone showed least disintegrating time of 11.67±0.88 seconds along with rapid drug release (98.88% within 15 minutes).

Dhaka Univ. J. Pharm. Sci. 15(1): 73-81, 2016 (June)

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Author Biography

Md Mizanur Rahman Moghal, Department of Pharmacy, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902



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Published

2016-08-08

How to Cite

Moghal, M. M. R., Mazumder, S. C., Lira, D. N., & Rouf, A. S. S. (2016). Fabrication and in vitro Evaluation of Allopurinol Fast Dissolving Tablets Using Croscarmellose Sodium, Sodium Starch Glycolate and Crospovidone as Superdisintegrants. Dhaka University Journal of Pharmaceutical Sciences, 15(1), 73–81. https://doi.org/10.3329/dujps.v15i1.29199

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