Characterization of Nanoemulsion Prepared from Self-emulsifying Rifampicin and its Antibacterial Effect on Staphylococcus aureus and Stap. epidermidis Isolated from Acne

Authors

  • Kohinur Begum Department of Pharmacy, ASA University Bangladesh, ASA Tower, Shyamoli, Dhaka 1207
  • Amit Sarker Department of Pharmacy, Primeasia University, Banani, Dhaka 1213
  • Israt Jahan Shimu Department of Pharmacy, Primeasia University, Banani, Dhaka 1213
  • Md Mazharul Islam Chowdhury Department of Pharmacy, ASA University Bangladesh, ASA Tower, Shyamoli, Dhaka 1207
  • Reza ul Jalil Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka1000

DOI:

https://doi.org/10.3329/dujps.v14i2.28507

Keywords:

Rifampicin nanoemulsion, entrapment efficiency, in vitro drug release, pH stability

Abstract

In this study, three different self emulsifying drug delivery systems of rifampicin (SEDD-R) were made using oleic acid and different surfactants such as Tween 80, Chremophor RH 40 and Chremophor EL designated as RN-TW, RN-CRH and RN- CEL. These self-emulsifying systems were converted to rifampicin nanoemulsion by adding water under sonication. The resulting particle sizes were found to be 192.7 nm, 183.4 nm and 179.2 nm for RN- CEL, RN-CRH and RN-TW, respectively using Zetasizer. Drug content, entrapment efficiency, in vitro drug release and pH stability tests was performed. Drug content and entrapment efficiency for RNTW, RN-CRH and RN- CEL were found as 0.9945% & 0.9835%, 0.9720% & 84.31% and 74.58 % & 56.89%, respectively. The release of drug from RN-TW, RN-CRH and RN-CEL occurred for 450-, 330- and 240- minutes, respectively. The pH stability study demonstrated that all formulations retained maximum drug at pH 5.8. Antibacterial effect of the preparations was evaluated against S. epidermidis and S. aureus isolated from acne and showed effective results.

Dhaka Univ. J. Pharm. Sci. 14(2): 171-177, 2015 (December)

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Author Biography

Kohinur Begum, Department of Pharmacy, ASA University Bangladesh, ASA Tower, Shyamoli, Dhaka 1207



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Published

2016-06-28

How to Cite

Begum, K., Sarker, A., Shimu, I. J., Chowdhury, M. M. I., & Jalil, R. ul. (2016). Characterization of Nanoemulsion Prepared from Self-emulsifying Rifampicin and its Antibacterial Effect on Staphylococcus aureus and Stap. epidermidis Isolated from Acne. Dhaka University Journal of Pharmaceutical Sciences, 14(2), 171–177. https://doi.org/10.3329/dujps.v14i2.28507

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