Studies of the Effect of Storage Conditions on Some Pharmaceutical Parameters of Powders and Tablets

Authors

  • Bakre Lateef Gbenga Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu
  • Yusuf Taiwo Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu

DOI:

https://doi.org/10.3329/dujps.v14i2.28503

Keywords:

Pharmaceutical powders and tablets, relative humidity, sunlight, telecommunication mast radiation, stability

Abstract

This study evaluates the effect of storage conditions on some pharmaceutical parameters of powders (paracetamol, corn starch, tragacanth and polyvinyl pyrrolidone) and tablets (paracetamol, metronidazole and vitamin C). For powdered samples, angle of repose, bulk and tapped densities were determined while the tablets were evaluated for hardness, friability and disintegration before and after exposure to various humidity conditions, radiations from telecommunication mast and sunlight at intervals of 24 hrs & 1, 2, 4 and 8 weeks. The results showed a decrease in the angle of repose for paracetamol, corn starch, polyvinyl pyrollidone and tragacanth powders on exposure to sunlight. There was no significant (p>0.05) change in the tapped and bulk densities under the different storage conditions over the storage period. No organoleptic changes were observed for any of the samples stored under the environmental conditions over the two-month period. All the tablets stored over the two- month period conformed to the official BP standard for weight uniformity. Paracetamol tablets exposed to 93% relative humidity (RH) showed significantly lower reduction (P<0.05) in hardness compared to the other storage conditions. On prolonged exposure of paracetamol and metronidazole tablets to radiation from telecommunication mast, there was a reduction in tablet hardness and the tablets became friable. The observations of the present study reconfirm the role of storage conditions in ensuring the physical stability of pharmaceutical powders and tablets.\

Dhaka Univ. J. Pharm. Sci. 14(2): 147-151, 2015 (December)

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Author Biography

Bakre Lateef Gbenga, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu



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Published

2016-06-28

How to Cite

Gbenga, B. L., & Taiwo, Y. (2016). Studies of the Effect of Storage Conditions on Some Pharmaceutical Parameters of Powders and Tablets. Dhaka University Journal of Pharmaceutical Sciences, 14(2), 147–151. https://doi.org/10.3329/dujps.v14i2.28503

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