Gallic Acid Derivatives (GADs) from Loranthus micranthus Linn. Parasitic on Hevea brasiliensis with Antioxidative Capacity

  • Matthias Onyebuchi Agbo Department of Pharmaceutical and Medicinal Chemistry, University of Nigeria Nsukka, Enugu State Nigeria and Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, Düsseldorf
  • Kenneth Maduabuchi Ezealisiji Department of Pharmaceutical and Medicinal Chemistry, University of Port-Harcourt Rivers State
  • Joshua Elijah Parker Department of Biochemistry, University of Nigeria Nsukka, Enugu State
  • Francis Ikechukwu Ukekwe Department Morbid Anatomy, University of Nigeria, Enugu Campus, P.M.B. 01129, Enugu 400241
  • Wilfred Ofem Obonga Department of Pharmaceutical and Medicinal Chemistry, University of Nigeria Nsukka, Enugu State Nigeria
Keywords: Loranthus micranthus, Structure elucidation, Gallic acid, Antioxidant, Oxidative stress

Abstract

Semi-preparative High Liquid Column Chromatographic separation of the ethyl acetate soluble fraction of a methanol extract of the leaves of Loranthus micranthus Linn. parasitic on Hevea brasiliensis (Willd. ex A. Juss.) led to the isolation of two gallic acid derivatives (1-2). The structures of the compounds were solved by using spectroscopic methods (1D and 2D NMR and mass spectroscopic data) as well as by comparison with literature values. The compounds were identified as 3,4,5-tri-O-methyl gallic acid (1) and methyl 3-O-methyl gallate (2). The antioxidant activity of the isolated compounds was evaluated by using DPPH assay. Compounds 1 and 2 showed strong antioxidative capacity with inhibitory concentration (IC50) values of 10.0 ± 0.03 and 45.0 ± 0.02 ?M, respectively.

Dhaka Univ. J. Pharm. Sci. 14(2): 139-145, 2015 (December)

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Author Biography

Matthias Onyebuchi Agbo, Department of Pharmaceutical and Medicinal Chemistry, University of Nigeria Nsukka, Enugu State Nigeria and Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, Düsseldorf


Published
2016-06-28
How to Cite
Agbo, M., Ezealisiji, K., Parker, J., Ukekwe, F., & Obonga, W. (2016). Gallic Acid Derivatives (GADs) from Loranthus micranthus Linn. Parasitic on Hevea brasiliensis with Antioxidative Capacity. Dhaka University Journal of Pharmaceutical Sciences, 14(2), 139-145. https://doi.org/10.3329/dujps.v14i2.28502
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Articles