Pharmacological Evaluation of Stem Bark of Callicarpa arborea Roxb.

  • Mahbubul Hoque Shihan Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka Dhaka-1000
  • Zobaer Al Mahmud Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka Dhaka-1000
  • Nazmul Qais Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka Dhaka-1000
  • Mohammad Riaz Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka Dhaka-1000
Keywords: Callicarpa arborea, stem bark, ethanol extract, analgesic, antioxidant, antimicrobial, clot lysis

Abstract

The ethanol extract of stem bark of Callicarpa arborea and its different fractions were investigated for various pharmacological properties. In the acetic acid-induced writhing inhibition assay, the ethanol extract and its chloroform and ethyl acetate soluble fractions at a dose of 200 mg/kg body weight significantly inhibited writhing response with 42.7%, 70.3% and 32.8% of inhibition, respectively. In the antioxidant assay by DPPH, the ethanol extract and its pet ether and chloroform soluble partitionates demonstrated significant free radical scavenging activity with IC50 values of 41.53, 14.59 and 71.2 ?g/mL, respectively. In the disc diffusion method, the carbon tetrachloride soluble materials showed potential antimicrobial activity against all the tested organisms with zone of inhibition ranging from 19-22 mm at a concentration of 400 ?g/disc. On the other hand, the pet ether soluble fraction induced significant clot lysis (30.43%) when compared to negative control. Our findings from the studies clearly indicate that the stem bark of C. arborea possesses potential antinociceptive, antioxidant, antimicrobial and thrombolytic activities, which further warrant its systematic chemical investigation in order to isolate the biologically active molecules.

Dhaka Univ. J. Pharm. Sci. 14(1): 111-116, 2015 (June

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Author Biography

Mahbubul Hoque Shihan, Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka Dhaka-1000


Published
2015-06-18
How to Cite
Shihan, M., Mahmud, Z., Qais, N., & Riaz, M. (2015). Pharmacological Evaluation of Stem Bark of Callicarpa arborea Roxb. Dhaka University Journal of Pharmaceutical Sciences, 14(1), 111-116. https://doi.org/10.3329/dujps.v14i1.23743
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Articles