Evaluation of Antioxidant, Analgesic and Cytotoxic Activities of Typha angustata L. Root

  • Fahrima Islam Pharmacy Discipline, Life Science School, Khulna University, Khulna-9208
  • Amir Hossain Pharmacy Discipline, Life Science School, Khulna University, Khulna-9208
  • Md Golam Hossain Pharmacy Discipline, Life Science School, Khulna University, Khulna-9208
  • Gazi Md Monjur Murshid Pharmacy Discipline, Life Science School, Khulna University, Khulna-9208
  • Md Mustafizur Rahman Pharmacy Discipline, Life Science School, Khulna University, Khulna-9208
Keywords: Typha angustata, antioxidant, analgesic, cytotoxic

Abstract

Ethanolic extract of the root of Typha angustata was evaluated for antioxidant, analgesic and cytotoxic activities. T. angustata extract exhibited DPPH free radical scavenging activity with IC50 value of 124.96 ± 0.93 ?g/ml. The total phenolic and tannin content were found to be 596.73 ± 1 mg GAE/100 g and 319.68 ± 64 mg GAE/100 g of dried plant material, respectively. Analgesic activity was determined using acetic acid induced writhing inhibition in mice model. The root extract, at doses of 250 mg/kg and 500 mg/kg body weight, showed inhibition of writhing reflex by 33.55% (p < 0.01) and 56.78% (p<0.001), respectively. Cytotoxicity of the extract was measured by brine shrimp lethality bioassay where the LC50 against brine shrimp nauplii was found to be 41.54?g/ml.

Dhaka Univ. J. Pharm. Sci. 14(1): 55-59, 2015 (June)

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Author Biography

Fahrima Islam, Pharmacy Discipline, Life Science School, Khulna University, Khulna-9208


Published
2015-06-18
How to Cite
Islam, F., Hossain, A., Hossain, M. G., Murshid, G. M., & Rahman, M. M. (2015). Evaluation of Antioxidant, Analgesic and Cytotoxic Activities of Typha angustata L. Root. Dhaka University Journal of Pharmaceutical Sciences, 14(1), 55-59. https://doi.org/10.3329/dujps.v14i1.23736
Section
Articles