Gastroentero-histopathology Studies of Synthesized Naproxen Esters in Young Healthy Sprague-Dawley Rat Model

  • Mansura Akter Department of Pharmacy, Faculty of Life & Earth Science, Jagannath University, Dhaka
  • Sajal Kumar Saha Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka
  • SM Abdur Rahman Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka
Keywords: Naproxen, esters, gastro-ulcergenecity, toxicities

Abstract

Naproxen and its synthesized esters namely naproxen methyl ester, C15H16O3 (compound 1), ethyl ester, C16H17O3 (compound 2) and isopropyl ester, C17H20O3 (compound 3) were subjected to NSAID induced gastro-ulcergenecity studies on young, healthy male rat model. Rats (Rattus novergicus: Sprague-Dawley strain) of 2-months old weighing 95105 g were administered with naproxen (10 mg/kg b.w.) compound 1 (10.609 mg/kg b.w.), compound 2 (11.217 mg/kg b.w.) and compound 3 (11.826 mg/kg b.w.) twice daily for 4.5 days. The naproxen esters appeared to induce significantly less GI injury and bleeding both in microscopic and macroscopic examinations. This study can be a basis of reference for further acute, chronic or subchronic toxicity studies in various in-vivo models.

Dhaka Univ. J. Pharm. Sci. 14(1): 49-53, 2015 (June)

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Author Biography

Mansura Akter, Department of Pharmacy, Faculty of Life & Earth Science, Jagannath University, Dhaka


Published
2015-06-18
How to Cite
Akter, M., Saha, S., & Rahman, S. (2015). Gastroentero-histopathology Studies of Synthesized Naproxen Esters in Young Healthy Sprague-Dawley Rat Model. Dhaka University Journal of Pharmaceutical Sciences, 14(1), 49-53. https://doi.org/10.3329/dujps.v14i1.23735
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Articles