Formulation and Evaluation of Ibuprofen Loaded Lipospheres for Effective Oral Drug Delivery

  • MA Momoh Drug Delivery Research Unit, Department of Pharmaceutics, University of Nigeria, Nsukka-410001
  • FC Kenechukwu Department of Pharmaceutics and Pharmaceutical Microbiology, Usmanu Danfodiyo University, Sokoto
  • MS Gwarzo Department of Pharmaceutical Technology and Raw Material Development, National Institute for Pharmaceutical Research and Development, Abuja
  • PF Builders Department of Pharmaceutical Technology and Raw Material Development, National Institute for Pharmaceutical Research and Development, Abuja
Keywords: Ibuprofen, lipospheres, drug delivery, sustained-release, characterization

Abstract

Ibuprofen (IBU) is an anti-inflammatory drug characterized by low solubility and bioavailabilty. This study was to develop IBU-liposphere and investigated for in vitro and in vivo performance. IBU free base was incorporated into lipospheres based on micronized beeswax and Phospholipon® 90H in the ratio of (1:3), via hot emulsification. IBU-loaded lipospheres were characterized based on morphology, encapsulation efficiency (EE%), and in vitro drug release. Analgesic, anti-inflammatory activities and the pharmacokinetics were similarly evaluated. Minimum and maximum encapsulation efficiency (EE%) of 89.4 and 97.9% were obtained for lipospheres A1 and A3, respectively. Stable, spherical and smooth lipospheres of size range 101 ± 0.30 to 178 ± 0.30 ?m were obtained. Minimum and maximum release of 75 and 96.9% were obtained for A1 and A3, respectively. Significant (p<0.005) analgesic and anti-inflammatory activities were achieved with prolong plasma concentration. IBU-lipospheres based on beeswax and phospholipid could be explored as an alternative drug delivery system.

Dhaka Univ. J. Pharm. Sci. 14(1): 17-27, 2015 (June)

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Author Biography

MA Momoh, Drug Delivery Research Unit, Department of Pharmaceutics, University of Nigeria, Nsukka-410001


Published
2015-06-18
How to Cite
Momoh, M., Kenechukwu, F., Gwarzo, M., & Builders, P. (2015). Formulation and Evaluation of Ibuprofen Loaded Lipospheres for Effective Oral Drug Delivery. Dhaka University Journal of Pharmaceutical Sciences, 14(1), 17-27. https://doi.org/10.3329/dujps.v14i1.23730
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Articles