Studies on Bio-adhesion of Matrix Tablets: I. Release Profile of Theophylline Anhydrous

  • Md. Shamsuddin Department of Pharmacy, The University of Asia Pacific, Dhaka-1209
  • Parvin Akter Department of Pharmacy, The University of Asia Pacific, Dhaka-1209
  • Md. Ziaur Rahman Khan Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Jakir Ahmed Chowdhury Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Md. Selim Reza Faculty of Pharmacy, University of Dhaka, Dhaka-1000
Keywords: Bio-adhesion, Release profile, theophylline anhydrous

Abstract

Controlled release matrix tablets of theophylline anhydrous were designed with different types of bioadhesive polymers. HPMC 15 cps and 50 cps, Na-CMC, Gelatin, Xanthun gum and PVP K-30 were selected to formulate matrix tablets. Tablets of theophylline were prepared by direct compression method and were subjected to in vitro drug dissolution for 8 hrs in a gastric fluid media by using thermal shaker with a shaking speed of 50 rpm at a temperature of 37 ± 0.5°C. The in vitro release study as well as retention time of bioadhesive tablets on mucous membrane were investigated to develop a bioadhesive polymer based controlled release delivery system and to evaluate the performance of such delivery device. Na-CMC, HPMC and Xanthan gum based tablets showed greater bio-adhesive strength where as gelatin and PVP K-30 based tablets showed poor bioadhesive strength. Na-CMC and Xanthun gum loaded tablets were not discharged from the mucous membrane and these tablets were fully dissolved in the gastric fluid. Xanthan gum, Na-CMC and HPMC based formulation showed nearly zero-order release. On the contrary, gelatin and PVP K-30 based formulation showed a burst release within one hour of dissolution. Key words: Bio-adhesion, Release profile, theophylline anhydrous. Dhaka Univ. J. Pharm. Sci. Vol.5(1-2) 2006 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

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How to Cite
Shamsuddin, M., Akter, P., Khan, M., Chowdhury, J., & Reza, M. (1). Studies on Bio-adhesion of Matrix Tablets: I. Release Profile of Theophylline Anhydrous. Dhaka University Journal of Pharmaceutical Sciences, 5(1), 33-37. https://doi.org/10.3329/dujps.v5i1.226
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