<i>In vitro</i> Antimicrobial Activity of Some Synthetic Isoindolinone and Isoquinolinone Derivatives

  • AFG Masud Reza Department of Chemistry, National University, Gazipur-1704
  • Md. Wahab Khan Department of Chemistry, Bangladesh University of Engineering and Technology, Dhaka-1000
  • Mohammad S Rahman Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Chowdhury M Hasan Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Mohammad A Rashid Centre for Biomedical Research, University of Dhaka, Dhaka-1000
Keywords: 2-iodo-N-substituted benzamide, Isoindolinone, Isoquinolinone, Antimicrobial assay, Disc diffusion.

Abstract

A total of six N-substituted benzamides, eight isoindolinone derivatives and six isoquinolinone analogs have been screened against five Gram positive and twelve Gram negative bacteria as well as four human fungal pathogens. From the antimicrobial screening, it is evident that 2-iodo-N-subustituted tetrahydro-1-oxo isoquinoline-3-carboxylic acids showed very prominent activity at a concentration 200 µg/disc, while the N-subtituted-3-alkyl isoindolin-1-one acetates showed weak to moderate activity. At the same time, 2-iodo-N-subustituted benzamides revealed very poor activity. Key words: 2-iodo-N-substituted benzamide, Isoindolinone, Isoquinolinone, Antimicrobial assay, Disc diffusion. Dhaka Univ. J. Pharm. Sci. Vol.5(1-2) 2006 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

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How to Cite
Reza, A., Khan, M., Rahman, M., Hasan, C., & Rashid, M. (1). <i>In vitro</i&gt; Antimicrobial Activity of Some Synthetic Isoindolinone and Isoquinolinone Derivatives. Dhaka University Journal of Pharmaceutical Sciences, 5(1), 15-19. https://doi.org/10.3329/dujps.v5i1.222
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