Preliminary phytochemical screenings and Pharmacological activities of Blumea lacera (Burn.f.) DC.

  • Md Abul Khair Department of Pharmacy, Southern University Bangladesh, Chittagong
  • Mohammed Ibrahim Department of Pharmacy, Southern University Bangladesh, Chittagong
  • Qamrul Ahsan Department of Pharmacy, Southern University Bangladesh, Chittagong
  • Md Ruhul Kuddus Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
  • Ridwan Bin Rashid Department of Microbiology, University of Dhaka, Dhaka-1000
  • Mohammad Abdur Rashid Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000
Keywords: Blumea lacera, phytochemical, antipyretic, analgesic, anti-inflammatory

Abstract

The methanol extract of the whole plant of Blumea lacera (Burn.f.) DC. (BLME) has been subjected to preliminary screenings for phytoconstituents and antipyretic, analgesic and anti-inflammatory activities. Antipyretic activity was assessed by the yeast-induced hyperthermia in mice. The analgesic property was evaluated by formalin-induced writhing test. Acetyl salicylic acid (ASA) was used as standard for in-vitro anti-inflammatory activity test. In yeast-induced pyrexia, the crude extract demonstrated a significant (p=0.05) reduction in body temperature of mice after elevation by the administration of yeast. These effects were pronounced at the 2nd and 3rd h of post-treatment with the extract. BLME exhibited a dose-dependent analgesic activity with 39.13% and 56.52% protection at 200-and 400-mg/kg, b.w., respectively as compared to 76.09% revealed by the standard diclofenac sodium. In the anti-inflammatory test, the crude extract at 400 ?g/ml displayed 62.40% inhibition of protein denaturation whereas standard acetyl salicylic acid exhibited 76.74% inhibition. Results of the preliminary phytochemical screenings demonstrated the presence of alkaloids, flavonoids and triterpenoids in the extract.

DOI: http://dx.doi.org/10.3329/dujps.v13i1.21863

Dhaka Univ. J. Pharm. Sci. 13(1): 69-73, 2014 (June)

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Abstract
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Published
2015-02-03
How to Cite
Khair, M. A., Ibrahim, M., Ahsan, Q., Kuddus, M. R., Rashid, R. B., & Rashid, M. A. (2015). Preliminary phytochemical screenings and Pharmacological activities of Blumea lacera (Burn.f.) DC. Dhaka University Journal of Pharmaceutical Sciences, 13(1), 69-73. https://doi.org/10.3329/dujps.v13i1.21863
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Articles